Analgesic and anti-diarrhoeal activities of Lagerstroemia speciosa roots in experimental animal model

  • Fahad Hussain Department of Pharmacy, Noakhali Science and Technology University, Noakhali
  • Amlan Ganguly Department of Pharmacy, Faculty of Life and Earth Science, Jagannath University, Dhaka-1100
  • Mohammad Salim Hossain Department of Pharmacy, Noakhali Science and Technology University, Noakhali
  • SM Abdur Rahman Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
Keywords: Lagerstroemia speciosa, analgesic, writhing, anti-diarrhoeal, castor oil, Swiss albino mice

Abstract

The methanolic crude extract of Lagerstroemia speciosa roots was investigated for its possible analgesic and anti-diarrhoeal activities in experimental animal model. Phytochemical screening of the methanolic extract of L. speciosa roots showed the presence of alkaloids, flavonoids, saponins, tannins and reducing sugar. In acute toxicity study, no mortality or toxic reaction was recorded in animal model after administration of the L. speciosa roots extract. Analgesic activity was evaluated by using acetic acid induced writhing inhibition method in Swiss albino mice. In peripheral method of anti-nociception, the methanolic crude extract of L. speciosa roots showed significant analgesic activity. At the dose of 200 and 400 mg/kg body weight, the extract produced 35.38% and 53.85% (P<0.001) of writhing inhibition, respectively compared to standard diclofenac sodium (70.77% inhibition). The extract had also anti-diarrhoeal activity in castor oil induced method and inhibited the mean number of defecation by 32.75% (P<0.01) and 51.72 % (P<0.001) at the dose of 200 and 400 mg/kg body weight, respectively. The latent period for the extract treated group also increased significantly.

DOI: http://dx.doi.org/10.3329/dujps.v13i1.21860

Dhaka Univ. J. Pharm. Sci. 13(1): 57-62, 2014 (June)

Downloads

Download data is not yet available.
Abstract
976
PDF
1939
Published
2015-02-03
How to Cite
Hussain, F., Ganguly, A., Hossain, M. S., & Rahman, S. (2015). Analgesic and anti-diarrhoeal activities of Lagerstroemia speciosa roots in experimental animal model. Dhaka University Journal of Pharmaceutical Sciences, 13(1), 57-62. https://doi.org/10.3329/dujps.v13i1.21860
Section
Articles