Impact of Urinary Arsenic Level on Simple Diffuse Goiter

Abstract

The impacts of urinary arsenic level on simple diffuse goiter was studied in Bangladeshi population. A correlation of urinary iodine, radioiodine uptake, thyroid stimulating hormone (THS) and free thyroxin (FT₄) levels was made on urinary arsenic level using a case-control analytical study. Out of 85 subjects 45 were considered for experimental group with simple diffuse goiter and rest 40 were considered for healthy control group without any thyroid disease. From the experimental results it has been found that iodine deficiency is not only the factor of causing simple diffuse goiter, but arsenic level is also one of the most important factors of causing simple diffuse goiter. It has also been found that the radioiodine uptake levels at 2 hours and 24 hours and the serum FT₄ have negative impacts on arsenic levels for both the experimental and control group. Their impacts are not statistically significant except the variable radioiodine uptake levels at 24 hours. The serum TSH has positive impact on arsenic level for both experimental and control groups but not statistically significant. The estimated results revealed that the variable radioiodine uptake level at 24 hours play the significant role for reducing arsenic level.

Key words: Urinary Arsenic, Iodine Deficiency, Simple Diffuse Goiter, Urinary iodine, Thyroid Stimulating Hormone, Free Thyroxin and Radioiodine Uptake Level

doi: 10.3329/dujps.v7i2.2173    

Dhaka Univ. J. Pharm. Sci. 7(2): 161-168, 2008 (December)