The in vitro Antimycobacterial investigation of some basic meta-/para-Alkoxyphenylcarbamic Esters Bearing 4-(4-Fluoro/2-methoxyphenyl)piperazin-1-yl fragment

Authors

  • Ivan Malik Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava
  • Eva Sedlarova Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava,
  • Jozef Csollei Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackého 1-3, 612 42 Brno
  • Lukas Stanzel Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava
  • Lubica Sichrovska Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava
  • Jirina Stolarikova Laboratory for Mycobacterial Diagnosis and Tuberculosis, Institute of Public Health in Ostrava, Partyzánské nám. 7, 702 00 Ostrava

DOI:

https://doi.org/10.3329/dujps.v12i2.17621

Keywords:

Antimycobacterial activity, meta-/para-alkoxyphenylcarbamic acid esters, arylpiperazines

Abstract

Following previous systematical research of ortho-/meta-/para-alkoxyphenylcarbamic acid esters as antimycobacterially active compounds, the set of the derivatives containing meta-/para-alkoxyphenylcarbamoyloxy and 4-(4-fluorophenyl/2-methoxyphenyl)piperazin-1-yl moieties were tested for their in vitro activity against tuberculous strain of Mycobacterium (M.) tuberculosis CNCTC My 331/88 as well as against potential pathogenic strains of M. kansasii CNCTC My 235/80, M. avium CNCTC My 330/88 and M. kansasii 6 509/96, respectively, by applying the micromethod for the determination of the minimum inhibitory concentration (MIC). It is concludut that the molucules posscssed selatively promising activity against M. Tuberculasis and M. Kansas!!.

Dhaka Univ. J. Pharm. Sci. 12(2): 103-107, 2013 (December)

DOI: http://dx.doi.org/10.3329/dujps.v12i2.17621

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Published

2014-01-12

How to Cite

Malik, I., Sedlarova, E., Csollei, J., Stanzel, L., Sichrovska, L., & Stolarikova, J. (2014). The in vitro Antimycobacterial investigation of some basic meta-/para-Alkoxyphenylcarbamic Esters Bearing 4-(4-Fluoro/2-methoxyphenyl)piperazin-1-yl fragment. Dhaka University Journal of Pharmaceutical Sciences, 12(2), 103–107. https://doi.org/10.3329/dujps.v12i2.17621

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