Formulation and evaluation of compression Coated tablets of Lornoxicam for Targeting early morning peak symptoms of Rheumatoid arthritis

Authors

  • Mohd Abdul Hadi Department of Pharmaceutics, Bhaskar Pharmacy College (JB Group of Educational Institutions), Yenkapally (V), Moinabad (M), R.R.District, Hyderabad-500075, Andhra Pradesh
  • NG Raghavendra Rao Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Thimmapur, Karimnagar -505481, Andhra Pradesh
  • A Srinivasa Rao Bhaskar Pharmacy College (JB Group of Educational Institutions), Yenkapally (V), Moinabad (M), R.R.District, Hyderabad-500075, Andhra Pradesh

DOI:

https://doi.org/10.3329/dujps.v12i2.17620

Keywords:

Pulsatile formulation, Lornoxicam, Rheumatoid arthritis, Chronotherapeutic pattern, Compression coated tablets

Abstract

In the present research work, we have designed a pulsatile formulation of lornoxicam to treat rheumatoid arthritis as per the chronotherapeutic pattern of the disease. Core tablets were prepared by incorporating different concentration of disintegrants and were compressed in between different concentration and combination of hydrophobic and hydrophilic polymers. The core and compression coated tablets were subjected to pre-formulation, physicochemical, in-vitro drug release and stability studies. FTIR and DSC studies revealed that there was not any chemical reaction between pure drug lornoxicam and polymers. The pre and post-compressional parameters of tablets were also found to be within limits. The core tablets which were incorporated with 10% of crospovidone were found to be as most fastly disintegrating. Our optimized formulation F-5 releases lornoxicam after a lag time of 5.5±0.7 hours and 99.81±0.81% upto 8 hours. Stability was also found for the optimized formulation according to ICH guidelines.

Dhaka Univ. J. Pharm. Sci. 12(2): 109-117, 2013 (December)

DOI: http://dx.doi.org/10.3329/dujps.v12i2.17620

Downloads

Download data is not yet available.
Abstract
970
PDF
1716

Downloads

Published

2014-01-12

How to Cite

Hadi, M. A., Rao, N. R., & Rao, A. S. (2014). Formulation and evaluation of compression Coated tablets of Lornoxicam for Targeting early morning peak symptoms of Rheumatoid arthritis. Dhaka University Journal of Pharmaceutical Sciences, 12(2), 109–117. https://doi.org/10.3329/dujps.v12i2.17620

Issue

Section

Articles