Study and Evaluation of Release Kinetics of Tramadol HCl from Lipid Based Sustained Release Capsules by Melt Matrix

Authors

  • Irin Dewan Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209
  • Ananta Saha Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209
  • SM Ashraful Islam Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209
  • Mahjabeen Gazi Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209
  • Tasnuva Amin Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209
  • Sayeeda Fahmee Chowdhury Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209

DOI:

https://doi.org/10.3329/dujps.v11i2.14572

Keywords:

Melt matrix, Tramadol hydrochloride, hard gelatin capsule shell, dissolution, lipid materials

Abstract

The aim of our study was to improve the dissolution of Tramadol hydrochloride (TH) via its semisolid filled lipid based capsules. Sustained release formulation is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. Semisolid matrixes of TH were prepared by melt-matrix method and were filled in hard gelatin capsule shell (size 0). In this experiment, a mixture of Glycerol monostearate (GMS) and lipid materials like different lipophilic oils and surfactants were used to improve the matrix integrity and drug release. The effects of different oils like Arachis oil, Soyabean oil, castor oil, neobee oil and olive oil and different surfactants such as Span 80, Tween 80, PEG 400, Chremophore RH 40, Cremophor EL were analyzed by formulating at various ratios. The matrices were subjected to the paddle dissolution method using 900 ml of phosphate buffer (pH 6.8). The dissolution test was performed at 100 RPM and the temperature was set at 37 ± 0.50C. The amount of drug was measured from the absorbance with a UV spectrophotometer at 270 nm. The release of drug was plotted in zero order-, 1st order- and Higuchi-release patterns. The correlation coefficients values of the trend lines of the graphs revealed that the formulations best fit in Higuchian release pattern. So it can be said that the pharmaceutical quality of Tramadol HCl capsules can be improved by using a semisolid lipophilic matrix filled in hard gelatin capsules.

DOI: http://dx.doi.org/10.3329/dujps.v11i2.14572

Dhaka Univ. J. Pharm. Sci. 11(2): 137-145, 2012 (December)

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Published

2013-04-15

How to Cite

Dewan, I., Saha, A., Islam, S. A., Gazi, M., Amin, T., & Chowdhury, S. F. (2013). Study and Evaluation of Release Kinetics of Tramadol HCl from Lipid Based Sustained Release Capsules by Melt Matrix. Dhaka University Journal of Pharmaceutical Sciences, 11(2), 137–145. https://doi.org/10.3329/dujps.v11i2.14572

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