Antimicrobial, Antioxidant and Cytotoxic Activities of Glochidion multiloculare (Roxb. ex Willd.) Müll. Arg. (Euphorbiaceae)

Authors

  • ATM Zafrul Azam Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Abdullah Al Hasan Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Gias Uddin Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Mohammad Mehedi Masud Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Choudhury Mahmood Hasan Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v11i2.14560

Keywords:

Glochidion, antimicrobial, brine shrimp lethality bioassay, total phenolic content, free radical scavenging

Abstract

The methanol extract (ME) of the powdered bark of Glochidion multiloculare and its six vacuum liquid chromatographic (VLC) fractions (Fa-f) were investigated for antimicrobial, cytotoxic and antioxidant activities. Only fractions Fc and Fd showed mild antimicrobial activity. Significant free radical (DPPH) scavenging activity was found in Ff (IC50 value = 9.27±0.117 ?g/ml). The total phenolic content was measured involving Folin-Ciocalteu reagent and it was the highest in fraction Fe (187.00±1.74 mg of GAE/gm of sample). Cytotoxicity (LC50) by brine shrimp lethality bioassay was found to be significant for Fb (0.023±0.001 ?g/ml), Fc (0.3±0.01 ?g/ml) and Fd (0.117±0.0015 ?g/ml).

DOI: http://dx.doi.org/10.3329/dujps.v11i2.14560

Dhaka Univ. J. Pharm. Sci. 11(2): 117-120, 2012 (December)

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Published

2013-04-14

How to Cite

Azam, A. Z., Hasan, A. A., Uddin, M. G., Masud, M. M., & Hasan, C. M. (2013). Antimicrobial, Antioxidant and Cytotoxic Activities of Glochidion multiloculare (Roxb. ex Willd.) Müll. Arg. (Euphorbiaceae). Dhaka University Journal of Pharmaceutical Sciences, 11(2), 117–120. https://doi.org/10.3329/dujps.v11i2.14560

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