In vitro Interaction of Metformin with Diclofenac in Aqueous Medium

Authors

  • Shuvashis Saha Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Rehana Begum Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Zakir Sultan Centre for Advanced Research in Sciences (CARS), University of Dhaka, Dhaka-1000
  • Farhad Md Amjad Dhaka Medical College, Dhaka-1000
  • Md Shah Amran Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Amjad Hossain Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v11i2.14555

Keywords:

Metformin, Diclofenac, interaction

Abstract

Combination therapy may be unavoidable and common way for the treatment of disease where two or more drugs are given concurrently. The drugs may exhibit effects independently or may interfere with each other. Metformin is an anti-diabetic drug and diclofenac is a NSAID. The in vitro interaction of metformin with diclofenac was studied at room temperature and at different pH conditions. The studies were performed by various UV-Visible spectrophotometric, conductometric and HPLC methods. It was found that metformin formed stable 1:1 complex with diclofenac. The interaction may greatly influence the activity of these molecules.

DOI: http://dx.doi.org/10.3329/dujps.v11i2.14555

Dhaka Univ. J. Pharm. Sci. 11(2): 101-106, 2012 (December)

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Published

2013-04-14

How to Cite

Saha, S., Begum, R., Sultan, M. Z., Amjad, F. M., Amran, M. S., & Hossain, M. A. (2013). In vitro Interaction of Metformin with Diclofenac in Aqueous Medium. Dhaka University Journal of Pharmaceutical Sciences, 11(2), 101–106. https://doi.org/10.3329/dujps.v11i2.14555

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