In vitro Interaction of Nandrolone with Calcium Nitrate, Magnesium Sulfate and Potassium Permanganate in Aqueous Medium

Authors

  • Mehedi Afzal Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Zakir Sultan Drug Analysis and Research Laboratory, Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000
  • Rehana Begum Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Asma Rahman Drug Analysis and Research Laboratory, Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000
  • Md Shah Amran Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Amjad Hossain Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v11i2.14554

Keywords:

Nandrolone, drug-drug interaction, drug-metal interaction

Abstract

Nandrolone is an anabolic steroid drug that increases production and urinary excretion of erythropoietin. The drug is indicated with calcium nitrate, magnesium sulfate and potassium permanganate as concomitant uses. Therefore, there is a chance of interactions during concomitant use. Hence, we evaluated the interactions monitored by UV, conductometric titration and Ardon's spectrophotometric methods of nandrolone with calcium nitrate, magnesium sulfate and potassium permanganate at the ratio of 1: 1 at different pHs. It was found that nandrolone did not form any stable complexes at the ratio of 1:1 with the above mentioned salts.

DOI: http://dx.doi.org/10.3329/dujps.v11i2.14554

Dhaka Univ. J. Pharm. Sci. 11(2): 93-99, 2012 (December)

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Published

2013-04-14

How to Cite

Afzal, M., Sultan, M. Z., Begum, R., Rahman, A., Amran, M. S., & Hossain, M. A. (2013). In vitro Interaction of Nandrolone with Calcium Nitrate, Magnesium Sulfate and Potassium Permanganate in Aqueous Medium. Dhaka University Journal of Pharmaceutical Sciences, 11(2), 93–99. https://doi.org/10.3329/dujps.v11i2.14554

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