Leaf Extract of Syzygium cumini Shows Anti-Vibrio Activity Involving DNA Damage

  • Nazmul Ahsan Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka-1000
  • Nilanjana Paul Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka-1000
  • Nazrul Islam Clinical Microbiology Laboratory, ICDDR,B. Moakhali, Dhaka-1212
  • Anwarul A Akhand Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka-1000
Keywords: Syzygium cumini, anti Vibrio activity, DNA fragmentation

Abstract

The aim of the study was to investigate the effect of an ethanol extract of leaf (EEL) of Syzygium  cumini against Vibrio cholerae serogroups Ogawa and Inaba. The antimicrobial activity of EEL was evaluated by the disc diffusion method against multi-drug resistant Ogawa and Inaba. The EEL effectively inhibited the growth of  both serogroups. This growth inhibition was accompanied by fragmentation of genomic DNA as revealed by agarose gel electrophoresis. This result suggested that the EEL might inhibit bacterial growth involving DNA damage either through activation of signal transduction pathways or through direct interaction of the metabolites present in the EEL with DNA. Therefore, EEL of S. cumini has potential growth inhibitory activity against multi drug resistant Vibrios. This inhibitory effect of EEL might be explored to develop effective candidate(s) to combat cholera.

DOI: http://dx.doi.org/10.3329/dujps.v11i1.12483

Dhaka Univ. J. Pharm. Sci. 11(1): 25-28, 2012 (June)

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Abstract
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Published
2012-11-04
How to Cite
Ahsan, N., Paul, N., Islam, N., & Akhand, A. (2012). Leaf Extract of Syzygium cumini Shows Anti-Vibrio Activity Involving DNA Damage. Dhaka University Journal of Pharmaceutical Sciences, 11(1), 25-28. https://doi.org/10.3329/dujps.v11i1.12483
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