Synthesis and Antimicrobial Studies of Some 4-(Substituted)-Ethanoylamino-3-Mercapto-5- (4-Substituted) Phenyl-1,2,4-Triazoles

  • Neeraj Upmanyu Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar-470003,
  • Sanjay Kumar Defence Research Development and Establishment, Jhansi Road, Gwalior-474001
  • Kamal Shah GLA Institute of Pharmaceutical Research, Mathura-281406
  • Pradeep Mishra GLA Institute of Pharmaceutical Research, Mathura-281406
Keywords: 1, 2, 4-Triazoles, zone of inhibition, antibacterial, antifungal

Abstract

Triazoles and triazoles with different substituent groups are found to possess diverse application in the  field of medicine and industry. A series of 4-(substituted) ethanoylamino-3-mercapto-5-(4-substituted) phenyl-1,2,4-  triazoles were synthesized as novel antimicrobial agents starting from different 4-substituted benzoic acids. The  chemical structures of these newly synthesized compounds were elucidated by IR, 1H NMR, 13C NMR, FAB+-mass  spectral data and elemental analyses. The antimicrobial activity of title compounds were examined against two gram  positive bacteria (Staphylococcus aureus, Bacillus subtilis), two gram negative bacteria (Escherichia coli,  Pseudomonas aeruginosa) and three fungi (Candida albicans, Aspergillus niger and Fusarium oxysporum) using disc  diffusion method. Some of the compounds bearing methoxy group exhibited moderate to good antibacterial and  antifungal activities.

DOI: http://dx.doi.org/10.3329/dujps.v11i1.12481

Dhaka Univ. J. Pharm. Sci. 11(1): 7-18, 2012 (June)

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Abstract
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Published
2012-11-04
How to Cite
Upmanyu, N., Kumar, S., Shah, K., & Mishra, P. (2012). Synthesis and Antimicrobial Studies of Some 4-(Substituted)-Ethanoylamino-3-Mercapto-5- (4-Substituted) Phenyl-1,2,4-Triazoles. Dhaka University Journal of Pharmaceutical Sciences, 11(1), 7-18. https://doi.org/10.3329/dujps.v11i1.12481
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