Synthesis and Antimicrobial Studies of Some 4-(Substituted)-Ethanoylamino-3-Mercapto-5- (4-Substituted) Phenyl-1,2,4-Triazoles

Abstract

Triazoles and triazoles with different substituent groups are found to possess diverse application in the  field of medicine and industry. A series of 4-(substituted) ethanoylamino-3-mercapto-5-(4-substituted) phenyl-1,2,4-  triazoles were synthesized as novel antimicrobial agents starting from different 4-substituted benzoic acids. The  chemical structures of these newly synthesized compounds were elucidated by IR, ¹H NMR, ¹³C NMR, FAB+-mass  spectral data and elemental analyses. The antimicrobial activity of title compounds were examined against two gram  positive bacteria (Staphylococcus aureus, Bacillus subtilis), two gram negative bacteria (Escherichia coli,  Pseudomonas aeruginosa) and three fungi (Candida albicans, Aspergillus niger and Fusarium oxysporum) using disc  diffusion method. Some of the compounds bearing methoxy group exhibited moderate to good antibacterial and  antifungal activities.

DOI: http://dx.doi.org/10.3329/dujps.v11i1.12481

Dhaka Univ. J. Pharm. Sci. 11(1): 7-18, 2012 (June)