Formulation and in vitro Evaluation of Betahistine Dihydrochloride Twice Daily Controlled Release Matrix Tablet

Authors

  • Asraful Islam Department of Pharmaceutical Technology,University of Dhaka,Dhaka-1000
  • Shimul Halder Department of Pharmaceutical Technology,University of Dhaka,Dhaka-1000
  • Sitesh Chandra Bachar Department of Pharmaceutical Technology,University of Dhaka,Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v10i2.11786

Keywords:

Betahistine Dihydrochloride, Methocel K4M CR, Methocel K15M CR, Methocel K 100 LVCR, Controlled release, Meniere's disease

Abstract

In order to reduce dosing frequency, a sustained release dosage form of betahistine dihydrochloride was developed as a twice daily controlled release tablet formulation that could be used to decrease vertigo resulted in Meniere's disease for a prolonged time. Six formulations were developed by using Methocel K4M CR, Methocel K15M CR and Methocel K 100 LVCR as single and combinations in different percentage. The tablets were prepared by wet granulation method. Physical properties of betahistine dihydrochloride granules and betahistine dihydrochloride matrix tablets were evaluated. The tablets were characterized for Betahistine Dihydrochloride release in both gastric simulated fluid (0.1 N HCl, pH 1.3) and simulated intestinal fluid (buffer solution pH 6.8). The data     were subjected to different models in order to evaluate their release kinetics and mechanisms. The results of the in vitro dissolution study indicate that most of the formulations showed above 80% of drug release in 12 hours but formulations (F-2 and F-4) met the official specification of release profile. Dissolution data were fitted to zero order equation, Higuchi square root law, Korsmeyer-Peppas model and Hixson-Crowell cube root law as these plots showed the highest value of linearity to evaluate kinetic data. The release of betahistine dihydrochloride was prolonged for 12 hours indicating the usefulness of the formulations for twice daily dosage forms, leading to improve efficacy, controlling the release and better patient compliance.

 

DOI: http://dx.doi.org/10.3329/dujps.v10i2.11786

 

Dhaka Univ. J. Pharm. Sci. 10(2): 93-100, 2011 (December)

 

 

Downloads

Download data is not yet available.
Abstract
1171
PDF
3221

Downloads

Published

2012-09-03

How to Cite

Islam, A., Halder, S., & Bachar, S. C. (2012). Formulation and in vitro Evaluation of Betahistine Dihydrochloride Twice Daily Controlled Release Matrix Tablet. Dhaka University Journal of Pharmaceutical Sciences, 10(2), 93–100. https://doi.org/10.3329/dujps.v10i2.11786

Issue

Section

Articles