Synthesis and Antimicrobial Screening of Three Triazole Derivatives

Authors

  • MH Morshed Department of Chemistry, Khulna University of Engineering and Technology, Khulna
  • MF Islam Department of Biochemistry & Molecular Biology, Rajshahi University, Rajshahi
  • MA Yousuf Department of Chemistry, Khulna University of Engineering and Technology, Khulna
  • GMG Hossain Department of Chemistry, University of Dhaka, Dhaka
  • JA Khanam Department of Biochemistry & Molecular Biology, Rajshahi University, Rajshahi
  • MA Salam Department of Chemistry, University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/dujps.v10i1.10014

Keywords:

Antimicrobial, MIC, MBC, Triazole derivatives.

Abstract

Due to the medicinal importance of triazole derivatives, the antimicrobial property of three synthesized triazole derivatives were screened in vitro against some Gram positive and Gram negative pathogenic bacteria and some pathogenic fungi. In this study, three compounds 2-(5-mercapto-4-phenyl-4H-[1,2,4] triazole-3-yl]-cyclohexa- 1,5-dienol (S1), 2-[5-mercapto-4-(2-mercapto-phenyl)-4H- [1,2,4] triazole-3-yl]-phenol (S2) and 4-[3-(2-hydroxyphenyl)- 5-mercapto-[1,2,4] triazole-4-yl]-benzene sulfonamide (S3) have been synthesized. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were assessed by serial dilution technique. The compounds showed moderate antimicrobial activity against all the tested organisms and the results are comparable to standard antibiotic kanamycin. The MIC values of the compounds were found to be in the range of 16~64μg/ml. The low MIC and MBC values and high sensitivity of pathogenic microorganisms to the compounds led to conclude that the triazole derivatives have potential antimicrobial properties.

DOI: http://dx.doi.org/10.3329/dujps.v10i1.10014

DUJPS 2011; 10(1): 43-47

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Published

2012-03-02

How to Cite

Morshed, M., Islam, M., Yousuf, M., Hossain, G., Khanam, J., & Salam, M. (2012). Synthesis and Antimicrobial Screening of Three Triazole Derivatives. Dhaka University Journal of Pharmaceutical Sciences, 10(1), 43–47. https://doi.org/10.3329/dujps.v10i1.10014

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Section

Articles