TY - JOUR AU - Masud, Sadruddin Al AU - Hasina, Kaniz AU - Huque, Muhammed Moinul PY - 2016/05/14 Y2 - 2024/03/28 TI - Comparison between the effects of Propranolol vs Prednisolone vs Prednisolone with Propranolol in the management of infantile hemangioma JF - Journal of Paediatric Surgeons of Bangladesh JA - J. paediatr. surg. Bangladesh VL - 5 IS - 2 SE - Original Articles DO - 10.3329/jpsb.v5i2.27722 UR - https://www.banglajol.info/index.php/JPSB/article/view/27722 SP - 41-44 AB - <p><strong>Background:</strong> Infantile hemangiomas are the most common soft tissue tumors in infancy, Systemic pharmacologic intervention is necessary for endangering, ulcerating, problematic, or life-threatening IHs . These include oral corticosteroid therapy as first-line treatment and interferon - alfa or vincristine as second- or third-line therapeutic agents. Since 2008, use of propranolol has come to the forefront because of its efficacy &amp; minimal side effects.</p><p><strong>Aims and Objectives:</strong> The purpose of this study was to compare the efficacy of orally administered propranolol versus prednisolone versus both in the treatment of potentially disfiguring or functionally threatening infantile hemangiomas.</p><p><strong>Material and Methods:</strong> A prospective study of 24 patients aged 1 week to 12 years child with infantile hemangiomas was randomized into three equal groups. These were as follows: A, Propranolol (1–2 mg/kg/d); B, Prednisolone (1–2 mg/kg/d); and C, receiving both for a minimum duration of 3 months. Dimensions, color, consistency, ultrasonography, photographic documentation based on Visual Analogue Scale (VAS) were recorded before and periodically after starting treatment. A minimum 75% improvement was considered as success with no regrowth up to 1 month of stopping treatment.</p><p><strong>Results:</strong> Mean initial response time (days) in A (4.0 ± 3.3 SD) and C (4.5 ± 3.4SD) was significantly lower than B (8.79 ± 7.8SD) Significant change in consistency was noted very early in A (24 hours) compared to B (8days) and C (6 days). VAS results are as follows: (a) color fading—significant reduction in A within 48 hours compared to B and C (b) flattening— more significant and earlier in A and C than B ,and (c) mean reduction in size: significant in A and C at 3 months), 6 months whereas in B, it was seen only at 6 months.</p><p><strong>Conclusions:</strong> Though it’s a ongoing study, only result of 24 patient had been analysed. Propranolol had a consistent, rapid therapeutic effect compared to prednisolone. A combination of the two had a comparable but not higher efficacy than propranolol alone. Prednisolone was associated with a higher number of complications, thereby decreasing patient compliance.</p><p>J. Paediatr. Surg. Bangladesh <strong>5</strong>(2): 41-44, 2014 (July)</p> ER -