TY - JOUR AU - Reza, AQM AU - Karim, Aparajita AU - Khan, Mahmood Hasan AU - Rahman, Kazi Atiqur AU - Joarder, Md Aliuzzaman AU - Rahman, Khondoker Mahbubur AU - Talukder, Shahab Uddin AU - Munwar, Shams AU - Ali, M Atahar AU - Ahmed, Tamzeed AU - Islam, HM Waliul AU - Bala, Poppy AU - Islam, Nighat AU - Bhuiyan, Azfar Hossain PY - 2022/05/27 Y2 - 2024/03/28 TI - Patent Foramen Ovale Device Closure in Cryptogenic Ischaemic Stroke: A Two Case Reports with Literature Review JF - Journal of National Institute of Neurosciences Bangladesh JA - J. Natl Inst. Neurosci Bangladesh VL - 8 IS - 1 SE - Case Reports DO - 10.3329/jninb.v8i1.59943 UR - https://www.banglajol.info/index.php/JNINB/article/view/59943 SP - 90-99 AB - <p>A patent foramen ovale (PFO) is highly prevalent in patients with strokes of unknown cause or cryptogenic strokes (CSs). It has been remain an unsolved question as to whether a PFO should be closed or not to prevent recurrent strokes in patients diagnosed with CS. A paradoxical embolism through a PFO is pointed as a leading cause of CS, especially in younger patients with low risk factors for stroke. It also remains an unsolved matter on type of anti-coagulation therapy, which would be better for patients with CS and a PFO. In addition, surgical and trans-cutaneous closure of a PFO has been proposed for the secondary prevention of stroke in patients with CS with PFO. Several randomized controlled trials have been conducted in recent years to test whether a PFO closure gives a significant benefit in the management of CS. Many investigators believed that a PFO was an incidental finding in patients with CS. However, meta-analyses and more recent specific trials have eliminated several confounding factors and possible biases and have also emphasized the use of a shunt closure over medical therapy in patients with CS. Therefore, these latest studies can possibly change the treatment paradigm in the near future.</p><p>Journal of National Institute of Neurosciences Bangladesh, January 2022; 8(1):90-99</p> ER -