TY - JOUR AU - Chowdhury, Yamin Shahriar AU - Rahman, Md Habibur AU - Jahan, Nusrat AU - Hossain, Muhammad Monir AU - Afroz, Mahbuba AU - Mollah, Md Abid Hossain PY - 2022/05/27 Y2 - 2024/03/29 TI - Comparison of Nifedipine and Captopril for the Control of Hypertension among Children with Acute Glomerulonephritis: A Randomized Control Trial JF - Journal of National Institute of Neurosciences Bangladesh JA - J. Natl Inst. Neurosci Bangladesh VL - 8 IS - 1 SE - Original Research Articles DO - 10.3329/jninb.v8i1.59929 UR - https://www.banglajol.info/index.php/JNINB/article/view/59929 SP - 28-32 AB - <p><strong>Background: </strong>As control of hypertension is crucial in patients with acute glomerulonephritis (AGN) to avoid life-threatening complications and deaths.</p><p><strong>Objectives: </strong>This study was done to see the efficacy of captopril and nifedipine to control hypertension in AGN in respect to their clinical response, duration and cost of treatment.</p><p><strong>Methodology: </strong>This randomized clinical trial was done among children ages ranging from 3 to 12 years who were suffering from AGN with hypertension and/or its complications. After enrolment the patients were randomly divided into two groups as Group A and Group B. Both groups received the standard management of AGN. In addition, children in group-A received captopril (dose 0.5 up to 6 mg/kg/day) and children in group B received nifedipine (0.25 up to 0.5 mg/kg/day). Their effectiveness in relation to timing of response, duration of therapy, side effects and cost effectiveness of the drugs were assessed statistically and at p value of &lt;0.05 the result was considered significant.</p><p><strong>Results: </strong>Mean systolic and diastolic blood pressure (BP) in group A were 134.8±9.31 and 94.97±6.33 mm Hg respectively and those in group B were 131.96±8.16 and 92.80±9.11 mm Hg respectively. After intervention both the drugs were found effective to normalize BP (BP &lt;90th centile). The mean time/duration taken to normalize BP by captopril was 4.86 ± 1.73 days and that by nifedipine was 2.17 ±1.73 days respectively and this difference is significant (p&lt;0.01). The mean total duration of treatment required for captopril was 6.75 ± 2.04 days and that for nifedepine was 3.67 ± 1.24 days and this is highly significant (p&lt;0.001). The average cost of captopril treatment was 11.95 ± 8.65 taka and that of nifedipine was 1.77±1.15 taka respectively and it is highly significant (p&lt;0.001). The mean duration of hospital stay in captopril group was 8.59 ± 2.64 days and that in nifedipine group was 5.53 ± 1.49 days and it was very significant (p&lt;0.005).</p><p><strong>Conclusion: </strong>Nifedipine is more effective to control BP in relation to its earlier clinical response, duration and cost of treatment than Captopril in children with AGN.</p><p>Journal of National Institute of Neurosciences Bangladesh, January 2022; 8(1):28-32</p> ER -