Association of Thyroid Stimulating Hormone With Thyroid Peroxidase Antibody in Apparently Healthy Pregnant Women

Authors

  • Nadira Haque Senior Consultant of Obstetrics and Gynecology, Kuwait-Bangladesh Friendship Government Hospital, Dhaka.
  • Neha Rauniyar Consultant of Obstetrician and Gynecology, Kulhudhuffushi Regional Hospital, Maldives..
  • Khairun Nahar Associate Professor of Obstetrics and Gynecology, BSMMU, Dhaka.
  • Nazmul Hosain Professor of Cardiac Surgery, Chittagong Medical College, Chattogram.
  • Laila Khaleda Junior Consultant of Obstetrics and Gynaecology, Maternal and Child Health Training Institute, Dhaka.
  • Dilip Kumar Mandal Consultant of Obstetrician and Gynaecologist, Dhaka.
  • Mst Tajmira Sultana Assistant Professor of Obstetric and Gynaecology, Dhaka Medical College, Dhaka.
  • Fahmida Bayes Kakan Junior Consultant of Obstetrics and Gynaecology, Upazilla Health Complex, Tangail.
  • Yeshey Dorjey Consultant of Obstetrician and Gynaecologist, Phuentsholing General Hospital, Bhutan.

DOI:

https://doi.org/10.3329/jcmcta.v34i2.83596

Keywords:

Pregnancy; Thyroid peroxidase antibody; Thyroid stimulating hormone.

Abstract

Background: Undiagnosed thyroid disorders have different maternal and fetal adverse outcome. Euthyroid pregnant women with thyroid peroxidase antibody could silently go to overt hypothyroidism, but these can be prevented by identifying the patient with positive thyroid peroxidase antibodies in their early gestation. Objective of the study is to determine the association of serum thyroid stimulating hormone with thyroid peroxidase antibody in apparently healthy pregnant women.

Materials and methods: This cross-sectional study was carried out in the Department of Obstetrics and Gynecology, BSMMU between Ist  March 2016 and 28 February 2017. A total of 245 apparently healthy pregnant  women were included in this study. These subjects were tested for Thyroid Peroxidase Antibody (TPO-Ab) serum Thyroid Stimulating Hormone (TSH) and serum Free Thyroxine (FT4).

Results: 71(29%) of women at first trimester were found to have TSH > 2.5 and TPO-Ab positive in 54 (22%). Out of these positive subjects 22(30.98%) have raised TSH (>2.5 mIU/L). FT4 was low in 7(3%) of all subjects.  

Conclusion: There is a remarkable correlation between TSH and TPO-Ab (p < 0.05) in first trimester of pregnancy. Thus TPO-Ab could be considered as a screening tool.

JCMCTA 2023 ; 34 (2) : 62-67

Downloads

Download data is not yet available.
Abstract
22
PDF
19

Downloads

Published

2025-08-25

How to Cite

Haque, N., Rauniyar, N., Nahar, K., Hosain, N., Khaleda, L., Mandal, D. K., … Dorjey, Y. (2025). Association of Thyroid Stimulating Hormone With Thyroid Peroxidase Antibody in Apparently Healthy Pregnant Women. Journal of Chittagong Medical College Teachers’ Association, 34(2), 62–67. https://doi.org/10.3329/jcmcta.v34i2.83596

Issue

Vol. 34 No. 2 (2023)

Section

Papers and Originals