Correlation of Serum Hepcidin Level with Marker of Inflammation and Iron Status in Chronic Kidney Disease Patients in Chattogram

Authors

  • Nayana Nazir Dialysis Medical Officer of Nephrology, Chittagong Medical College Hospital, Chattogram.
  • Noor Uddin Zahed Assistant Professor of Nephrology, Institute of Applied Health Sciences (IAHS) Chattogram.
  • Sayful Hasan Medical Officer of Pharmacology and Therapeutics, Chittagong Medical College, Chattogram.
  • Sadia Sultana Specialist in Nephrology, Evercare Hospital, Chattogram.
  • Tafhima Jannat Inshad Medical Officer, Upazila Health Complex, Lohagara, Chattogram.
  • Mohammad Qamrul Islam Indoor Medical Officer of Nephrology, Chittagong Medical College Hospital, Chattogram.
  • Mohammad Abu Kausar Medical Officer, Seamen’s Hostel Dispensary, Chittagong Port Health Office, Chattogram.
  • Mohammed Shafiul Haider Chowdhury Assistant Professor of Nephrology, Cox’s Bazar Medical College, Cox’s Bazar.
  • Syed Mahtab ul Islam Assistant Professor of Nephrology, Chittagong Medical College, Chattogram.
  • Md Nurul Huda Professor of Nephrology, Chittagong Medical College, Chattogram.

DOI:

https://doi.org/10.3329/jcmcta.v34i1.67323

Keywords:

Chronic Kidney Disease; C-reactive protein (CRP); Hepcidin; Hb; Iron profile; Serum creatinine.

Abstract

Background: Hepcidinis a novel biomarker to check the bioavailability of iron among Chronic Kidney Disease (CKD) patients across the world. The study was conducted to evaluate the relationship of serum Hepcidin level with inflammatory markers in CKD patients of stages 3-5.

Materials and methods: This cross-sectional observational study was carried out in the Department of Nephrology of Chittagong Medical College Hospital for a period of one year. Eighty-five conveniently selected CKD patients (Stage 3-5) of whom Haemoglobin (Hb) concentration, iron indices, serum creatinine, C-reactive Protein (CRP) and serum hepcidin were measured. Spearman’s rank correlation coefficient was estimated, and simple linear regression was conducted.  

Results: Most of the study participants were male, and over 40 years of age. Median serum creatinine was 6.0 (IQR: 3.8-9.9) mg/dl and eGFR was 9.0 (IQR: 6-14) ml/min/1.73m2.  However, serum ferritin was higher among the high hepcidin group (490.5 ng/ml) in comparison to that of the low hepcidin group (218 ng/ml). Similar findings were found for CRP (7 vs. 17) mg/l. A significant positive association of hepcidinwas found with the serum ferritin and a negative association with TIBC and TSAT.

Conclusions: Study results would help to prove the relevance of hepcidinmeasurement among CKD patients in Bangladesh.

JCMCTA 2023 ; 34 (1) : 95-99

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Published

2023-10-16

How to Cite

Nazir, N. ., Zahed, N. U. ., Hasan, S. ., Sultana, S. ., Inshad, T. J., Islam, M. Q. ., Kausar, M. A. ., Chowdhury, M. S. H. ., Islam, S. M. ul, & Huda, M. N. . (2023). Correlation of Serum Hepcidin Level with Marker of Inflammation and Iron Status in Chronic Kidney Disease Patients in Chattogram. Journal of Chittagong Medical College Teachers’ Association, 34(1), 95–99. https://doi.org/10.3329/jcmcta.v34i1.67323

Issue

Section

Papers and Originals