@article{Ali Al-Jaghthmi_Abu Zeid_2020, title={Hypoglycemic and hepatoprotective effect of Rhizophora mucronata and Avicennia marina against streptozotocin-induced diabetes in male rats}, volume={7}, url={https://www.banglajol.info/index.php/JAVAR/article/view/46383}, abstractNote={<p><strong>Objectives: </strong>Aqueous extracts of <em>Rhizophora mucronata </em>and <em>Avicennia marina </em>leaves were inves­tigated for their hepatoprotective potential in diabetic rats.</p> <p><strong>Materials and methods: </strong>One hundred twenty male albino rats were randomly assigned to eight equal groups (<em>n </em>= 15). The first group (control) comprised normal healthy rats, while the second to fifth groups were intraperitoneally injected with a single dose of streptozotocin (STZ) [60 mg/ kg body weight (BW)] for induction of diabetes. Group 2 was kept as positive diabetic control, while groups 3–5 were orally treated with aqueous extracts of <em>R. mucronata </em>(400 mg/kg BW), <em>A. marina </em>(400 mg/kg BW) and with a combination of ½ a dose of the two plants, respectively, for six weeks. Groups 6–8 were non-diabetic rats that orally received aqueous extracts of <em>R. mucronata </em>(400 mg/kg BW), <em>A. marina </em>(400 mg/kg BW), and a combination of ½ a dose of the two plants, respectively, for 6 weeks.</p> <p><strong>Results: </strong>STZ-induced diabetic rats showed a significant reduction in serum glucose and liver enzymes, increased serum insulin, Homeostasis Model Assessment of β-cells (HOMA-β), and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Histopathological and immuno­histochemical examinations of the liver revealed improved pathologic criteria in the plant extract treated diabetic rats compared with the remarkable changes which had been seen in STZ-induced diabetic rats.</p> <p><strong>Conclusion: </strong>This study suggests that the aqueous extract of <em>R. mucronata </em>or its combination with <em>A. marina </em>showed potent hypoglycemic and hepatoprotective effects for liver dysfunction, as well as histopathological and immunohistochemical changes in the liver of STZ-induced diabetic rats.</p> <p>J. Adv. Vet. Anim. Res., 7(1): 177-185, March 2020</p>}, number={1}, journal={Journal of Advanced Veterinary and Animal Research}, author={Ali Al-Jaghthmi, Obidallah Hamdan and Abu Zeid, Isam ELDin Mohamed ELAmin}, year={2020}, month={Mar.}, pages={177–185} }