TY - JOUR AU - Khan, Md Shirajul Islam AU - Khan, Usama Salman PY - 2022/10/16 Y2 - 2024/03/28 TI - Efficacy and Safety of Intralesional Vitamin D3 Injection in Recalcitrant Periungual Warts: A Randomized Controlled Trial JF - Journal of Armed Forces Medical College, Bangladesh JA - J. Armed Forces Med. Coll. VL - 18 IS - 1 SE - Original Papers DO - 10.3329/jafmc.v18i1.61247 UR - https://www.banglajol.info/index.php/JAFMC/article/view/61247 SP - 3-6 AB - <p><strong>Introduction: </strong>Although the treatment of recalcitrant warts is often disappointing due to its high recurrence rates, the intralesional injections of Vitamin D3 (as an immunotherapeutic molecule) may regulate epidermal cell proliferation.</p><p><strong>Objective: </strong>To evaluate whether intralesional vitamin D3 immunotherapy is efficient and secure in treating the recalcitrant periungual warts.</p><p><strong>Materials and Methods: </strong>This randomized controlled therapeutic trial was performed in the Department of Dermatology and Venereology of Combined Military Hospital, Dhaka from July 2018 to December 2019. A total of 64 participants’ having different sizes and duration of recalcitrant periungual warts were included. Half of them were injected with about 0.2ml vitamin D3 solution (600,000 IU, 15 mg/ml) at the base of the wart (Group-A) and the remaining participants were subjected to cryotherapy (Group-B). A follow-up period of 6 months following the last session was performed to detect any recurrence.</p><p><strong>Results: </strong>The mean age of participants in Group A and B were 25.9±12.6 and 26.4±12.4 years, respectively (78.1% male in Group-A and 62.5% in Group B). The size and duration of warts between the two groups were not statistically significant (p&gt;0.05). The treatment outcome in Group-A varied from excellent 19(59.4%) to significant 8(25.0%), moderate 3(9.4%), mild (3.1%), and no response 1(3.1%), whereas in Group-B, the results were as follows: excellent 13(40.6%), significant 3(9.4%), moderate 9(28.1%), mild 7(21.9%). The efficacy was significantly higher in Group-A when compared to Group-B (p &lt;0.05). Furthermore, the burning sensation, blister, erythema, hypopigmentation, depigmentation and skin atrophy were significantly higher in Group-B compared to Group-A. The recurrence of warts were 12.5% and 34.4% in Group-A and B respectively.</p><p><strong>Conclusion: </strong>Vitamin D3 injection is more effective and secure than cryotherapy in the treatment of periungual warts.</p><p>JAFMC Bangladesh. Vol 18, No 1 (June) 2022: 3-6</p> ER -