@article{Yazdi_Huda_Khan_Hasan_Ahmad_Rosie_2015, title={Comparison of efficacy and safety between Tacrolimus and Hydrocortisone acetate in 2-5 years old children with atopic dermatitis}, volume={10}, url={https://www.banglajol.info/index.php/JAFMC/article/view/22924}, DOI={10.3329/jafmc.v10i1.22924}, abstractNote={<p><strong>Introduction:</strong> Atopic dermatitis is a recurrent inflammatory skin disease with intense pruritus as its hallmark symptom. It often follows a chronic, relapsing course.</p> <p><strong>Objectives:</strong> This comparative study was done with an aim to find out the efficacy of Tacrolimus and Hydrocortisone acetate in 2-5 year old children with Atopic dermatitis.</p> <p><strong>Methods:</strong> This clinical trial was carried out on two equal groups of 60 patients. “Group A” was treated with topical tacrolimus ointment (0.03%) and “group B” with hydrocortisone acetate ointment (1%). Follow up was done at week 1, 2, 4, 8 and 12 of treatment for assessment of improvement and adverse event, which was measured by ‘overall clinical improvement in the physician’s global evaluation of clinical response’. Data was collected in a predesigned data collection sheet, and analysis was performed by SPSS program (Version 12).</p> <p><strong>Results:</strong> Excellent, marked and moderate improvement were observed in 19 (63.3%), 9 (30.0%), and 2(6.7%) patients of tacrolimus group and 1(3.3%), 2(6.7%) and 27(90.0%) patients of hydrocortisone group respectively. Tacrolimus group had significantly better improvement than hydrocortisone group (p<0.001). Skins burning at application site were observed significantly more in tacrolimus group 8(26.7%) than in hydrocortisone group 2 (6.7%). 53 JAFMC Bangladesh. Vol 10, No 1 (June) 2014</p> <p><strong>Conclusion:</strong> The study showed tacrolimus ointment is more effective than hydrocortisone acetate in the treatment of atopic dermatitis in paediatric patients.</p> <p>DOI: <a href="http://dx.doi.org/10.3329/jafmc.v10i1.22924">http://dx.doi.org/10.3329/jafmc.v10i1.22924</a></p> <p>Journal of Armed Forces Medical College Bangladesh Vol.10(1) 2014</p>}, number={1}, journal={Journal of Armed Forces Medical College, Bangladesh}, author={Yazdi, Quazi Salim and Huda, Md Shamsul and Khan, Abdul Latif and Hasan, Md Sayeed and Ahmad, Mushtaq and Rosie, Tawhida Nawazesh}, year={2015}, month={Apr.}, pages={53–58} }