TY - JOUR AU - Ganesh, Kumar AU - Archana, Dhyani AU - Preeti, Kathiyal PY - 2014/01/13 Y2 - 2024/03/29 TI - Galactosylated Albumin Nanoparticles Bearing Cimetidine JF - International Journal of Pharmaceutical and Life Sciences JA - Int. J. Pharma Life Sci. VL - 2 IS - 5 SE - Research Articles DO - 10.3329/ijpls.v2i5.17628 UR - https://www.banglajol.info/index.php/IJPLS/article/view/17628 SP - 202-229 AB - <p>The galacotsylated albumin nanoparticles were prepared for the selective delivery of Cimetidine to the asialoglycoprotein receptor (ASGP-R) which is particularly presents on mammalian hepatocytes. The albumin nanoparticles (NPs) were prepared by using desolvation method and efficiently conjugated with galactose. Various parameters such as particle size, % entrapment efficiency and drug loading efficiency, percentage yield, <em>in vitro </em>drug release, were determined. The size of nanoparticles (both plain and galactose coated) was found to be in range of 200-250 nm, and maximum drug payload was found to be 19.08% ± 1.10 .The maximum drug content was found to be 30.80% ± 0.3 and 27.09% ± 0.5 respectively in plain and galactose coated nanoparticles while the maximum entrapment efficiency was found to be 90.68% ± 0.5 and 91.75% ± 0.59 in plain and coated nanoparticles. It was also found that coating of nanoparticles increases the size of nanoparticles. From the in-vitro studies, it was concluded that increase in polymer concentration, decreases the drug releases from the nanoparticles.</p> <p>DOI: <a href="http://dx.doi.org/10.3329/ijpls.v2i5.17628">http://dx.doi.org/10.3329/ijpls.v2i5.17628</a></p> <p>International Journal of Pharmaceutical and Life Sciences, Volume 2(5) Dec 2013: 202-229</p> ER -