International Current Pharmaceutical Journal 2020-04-18T16:14:57+00:00 Asst. Prof. Naz Hasan Huda Open Journal Systems Published by the Saki Publishing Club. Full text articles available. The journal is also available on its own <a title="ICPJ" href="">website</a>.<br />ICPJ is now accepting online submissions. Register with the journal to submit your manuscript using the easy 5 step online submission process. Profilistic Study of Bioactivities of Extracts of Gongronema latifolium Incorporated with Alum on some Clinical Bacteria 2020-04-18T16:14:57+00:00 Lawrence O Amadi Nathaniel N Ngerebara Chidinma A Okafor <p>Profilistic study of bioactivities of aqueous, ethanolic and methanolic leaf extracts of <em>Gongronema latifolium</em> in combination with potassium aluminium sulphate (Alum) against some clinical bacterial pathogens were investigated by disc diffusion (DD) and Agar well diffusion (AWD) methods respectively. The leaf extracts at concentrations of 0.1-0.3g were reconstituted in sterile distilled water as well as 1.0-3.0g of alum prior to application. In-vitro bioactivity of various concentrations of the extracts and in combination with alum were evaluated by measuring diameter of inhibition zones (DIZs) respectively. Methanolic leaf extract (MLE) had the largest mean DIZs of 14.5±0.5 and 11.5±0.0mm on <em>Escherichia coli</em> and <em>Salmonella typhi,</em> with enhanced bioactivity of 19.5±0.7 and 17.5±0.7mm with alum against <em>Bacillus subtilis</em>, <em>Sal. typhi</em> and <em>Pseudomonas aeruginosa</em> by DD and AWD methods respectively. However, aqueous leaf extract (ALE) and ethanolic leaf extract (ELE) and their combinations depicted appreciable antibacterial activity on the pathogens but incomparable to MLE. Generally, there was enhancement of bioactivties with the incorporation of Alum to the leaf extracts (irrespective of solvent of extraction) on a dose response fashion particularly by AWD method. Furthermore, the low MIC values of &lt;0.05 to 0.2mg/ml on the bacteria with MLE and ALE, validates their potency and broad spectrum activity. In contrast, the very large DIZs of Ciprofloxacin (CP) reflects the beneficial impact of purified chemotherapeutics against pathogens. Thus, the improved efficacy of these extracts with alum would justify future application in ethnomedicine as well as in nutraceuticals/pharmaceuticals or in food systems as “green chemicals” or “biopreservatives”.<strong></strong></p><p>International Current Pharmaceutical Journal, October 2018, 6(12): 92-98</p><p> </p> 2018-10-15T09:00:46+00:00 ##submission.copyrightStatement##