Central nervous system activity of the methanol extracts of Helianthus annuus seeds in mice model

Authors

  • Rubab Tarannum Islam Department of Pharmacy University of Science and Technology Chittagong Chittagong- 4202
  • Ahmed Tanjimul Islam Medical officer Department of Neurology Chittagong Medical College and Hospital Chittagong- 4203
  • Mir Monir Hossain Department of Pharmacy University of Science and Technology Chittagong Chittagong- 4202
  • Kishor Mazumder Department of Pharmacy University of Science and Technology Chittagong Chittagong- 4202

DOI:

https://doi.org/10.3329/icpj.v5i1.25869

Keywords:

Sunflower seeds, asteraceae, general behaviour, antidepressant activity, anxiolytic activity

Abstract

Helianthus annuus seeds contain various chemical components and evaluate different biological activities. The present study was carried out to investigate the central nervous system (CNS) activity of methanolic extract of Helianthus annuus seeds in mice model. General behaviour, antidepressant activity and anxiolytic activity was observed. The results revealed that the methanol extract of Helianthus annuus seeds at 100 and 200 mg/kg caused a significant increase in the spontaneous activity (general behavioural profile), moderate increase in anxiolytic activity (light-dark box and elevated plus maze test) and remarkable increase in antidepressant activity (tail suspension test). The results suggest that methanol extract of Helianthus annuus exhibit significant antidepressant and moderate anxiolytic activity in tested animal models.

Islam et al., International Current Pharmaceutical Journal, December 2015, 5(1): 1-4

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Published

2015-12-07

How to Cite

Islam, R. T., Islam, A. T., Hossain, M. M., & Mazumder, K. (2015). Central nervous system activity of the methanol extracts of Helianthus annuus seeds in mice model. International Current Pharmaceutical Journal, 5(1), 1–4. https://doi.org/10.3329/icpj.v5i1.25869

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Section

Original Articles