Solid Lipid Nanoparticles (SLN): Method, Characterization and Applications

  • Akanksha Garud Department of Pharmaceutics, Institute of Professional Studies, College of Pharmacy, Gwalior, Madhya Pradesh 474002
  • Deepti Singh Department of Pharmaceutics, Institute of Professional Studies, College of Pharmacy, Gwalior, Madhya Pradesh 474002
  • Navneet Garud Department of Pharmaceutics, Institute of Professional Studies, College of Pharmacy, Gwalior, Madhya Pradesh 474002
Keywords: Solid lipid nanoparticles, drug delivery, drug incorporation

Abstract

Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Proteins and antigens intended for therapeutic purposes may be incorporated or adsorbed onto SLN, and further administered by parenteral routes or be alternative routes such as oral, nasal and pulmonary. The obstacles associated with conventional chemotherapy may be partially overcome by encapsulating them as SLN. The present review focuses on the utility of SLN in terms of their advantages, production methodology, characterization and applications. If properly investigated, SLNs may open new vistas in therapy of complex diseases.

DOI: http://dx.doi.org/10.3329/icpj.v1i11.12065

International Current Pharmaceutical Journal 2012, 1(11): 384-393

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Abstract
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PDF
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Published
2012-10-03
How to Cite
Garud, A., Singh, D., & Garud, N. (2012). Solid Lipid Nanoparticles (SLN): Method, Characterization and Applications. International Current Pharmaceutical Journal, 1(11), 384-393. https://doi.org/10.3329/icpj.v1i11.12065
Section
Review Articles