Benzimidazole: A short review of their antimicrobial activities

  • Namrata Singh Bharat Institute of Technology, School of Pharmacy, Bypass Road, Partapur, Meerut, Uttar Pradesh
  • Annamalai Pandurangan Bharat Institute of Technology, School of Pharmacy, Bypass Road, Partapur, Meerut, Uttar Pradesh
  • Kavita Rana Bharat Institute of Technology, School of Pharmacy, Bypass Road, Partapur, Meerut, Uttar Pradesh
  • Preeti Anand Bharat Institute of Technology, School of Pharmacy, Bypass Road, Partapur, Meerut, Uttar Pradesh
  • Arsad Ahamad Bharat Institute of Technology, School of Pharmacy, Bypass Road, Partapur, Meerut, Uttar Pradesh
  • Amit Kumar Tiwari Bharat Institute of Technology, School of Pharmacy, Bypass Road, Partapur, Meerut, Uttar Pradesh
Keywords: benzimidazoles, anti-malarial, anti-fungal, anti-bacterial, anti-viral

Abstract

Benzimidazole is the heterocyclic compound formed from benzene and imidazole ring containing nitrogen, oxygen sulphor and its derivatives are of wide interest because of their diverse biological activity and clinical applications, they are remarkably effective compounds both with respect to their inhibitory activity and their favourable selectivity ratio. Reported nucleus is a constituent of vitamin-B12. Benzimidazoles are regarded as a promising class of bioactive heterocyclic compounds that exhibit a range of biological activities like anti-microbial, anti-viral, anti-diabetic, anti-cancer activity, numerous anti-oxidant, anti-parasitic, anti-helmintics, anti-proliferative, anti-HIV, anti-convulsant, anti-inflammatory, anti-hypertensive, anti-neoplastic, proton pump inhibitor and anti-trichinellosis. Benzimidazoles exhibit significant activity as potential antitumor agents, smooth muscle cell proliferation inhibitors, a treatment for intestinal cystitis, and in diverse area of chemistry. Some of the important benzimidazole derivatives have been reported as thyroid receptor agonist gonadotropin releasing hormone receptor antagonists, non-nucleoside HIV-1 reverse transcriptase inhibitors and interestingly alkynylbenzimidazoles as modulators of metabotropic glutamate receptors. The imidazole core is a common moiety in a large number of natural products and pharmacologically active compounds. The synthesis of novel benzimidazole derivatives remains a main focus of medicinal research. This comprehensive overview summarizes the chemistry of different derivative of substituted benzimidazole along with their anti-microbial activity containing anti-malarial anti-fungal, anti-bacterial, anti-viral activities.

DOI: http://dx.doi.org/10.3329/icpj.v1i5.10284

International Current Pharmaceutical Journal 2012, 1(5): 119-127

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Published
2012-04-07
How to Cite
Singh, N., Pandurangan, A., Rana, K., Anand, P., Ahamad, A., & Tiwari, A. (2012). Benzimidazole: A short review of their antimicrobial activities. International Current Pharmaceutical Journal, 1(5), 110-118. https://doi.org/10.3329/icpj.v1i5.10284
Section
Review Articles