A Study on Efficacy of Oral Itraconazole in the Treatment of Seborrheic Dermatitis

Authors

  • Sahadev Kumar Adhikary Medical Officer, Department of Dermatology and Venereology, Khulna Medical College Hospital, Khulna, Bangladesh
  • Md Eakub Ali Professor, Dept. of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Bangladesh
  • Md Jamal Uddin Associate Prof, Dept. of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Bangladesh
  • Shireen Akter Assistant Professor, Department of Dermatology and venereology, Khulna Medical College, Khulna, Bangladesh
  • Masood Mohammad Abdul Aziz Assistant Professor and Head, Department of Biochemistry, Khulna City Medical College, Bangladesh
  • Farhana Ferdaus Assistant Professor and Head, Dept. of Community Medicine, Khulna City Medical College, Khulna, Bangladesh
  • Ratan Lal Dutta Banik Asst. Prof. (Skin & VD), OSD DGHS, Attached to Khulna Medical College, Bangladesh

DOI:

https://doi.org/10.3329/fmcj.v16i1.55732

Keywords:

Seborrheic dermatitis, Malassezia yeasts, Itraconazole

Abstract

Seborrheic dermatitis is a common chronic disease. Malassezia yeasts have been implicated in the pathogenesis of this disease. Antifungal agents are known to be effective in the treatment of Malassezia yeast infections. This study was done to evaluate the efficacy of itraconazole in the treatment of seborrheic dermatitis. Sixty patients with Seborrheic dermatitis were evaluated in an open non-comparative study. Patients were treated with itraconazole capsule 100 mg twice a day for a week; then after a 3-week interval 100 mg capsule was given twice a day for 2 days of following months for two consecutive months. Four clinical parameters (Itching, burning erythema, scaling, and seborrhea) were assessed using a 0 to 3-point (0= absent, 1 = mild, 2 = moderate, 3 = severe) score. Mycological evaluation determined the presence of Malassezia spores in the scales using a direct smear. At the end of the initial treatment significant improvement was reported in four clinical parameters: Itching, burning erythema, scaling, and seborrhea. Maintenance therapy led to further improvement slightly. Burning sensation mildly improved during the treatment. The quantity of Malassezia spores present in the direct smear decreased throughout the treatment period. Blood test abnormalities were not found during the treatment. So initial treatment with itraconazole is beneficial in patients with seborrheic dermatitis.

Faridpur Med. Coll. J. 2021;16(1):21-24

Downloads

Download data is not yet available.
Abstract
188
PDF
78

Downloads

Published

2021-10-03

How to Cite

Adhikary, S. K. ., Ali, M. E. ., Uddin, M. J. ., Akter, S. ., Abdul Aziz, M. M. ., Ferdaus, F. ., & Dutta Banik, R. L. . (2021). A Study on Efficacy of Oral Itraconazole in the Treatment of Seborrheic Dermatitis. Faridpur Medical College Journal, 16(1), 21–24. https://doi.org/10.3329/fmcj.v16i1.55732

Issue

Section

Original Articles