Association of Serum High Sensitivity C-Reactive Protein with Insulin Resistance in Patients with Type-ΙΙ Diabetes Mellitus

Authors

  • Nadia Hossain Assistant Professor, Dept. of Biochemistry, Chattogram Maa-O-Shishu Hospital Medical College, Bangladesh
  • Mahmudul Haque Professor & Ex-head, Dept. of Biochemistry, Chittagong Medical College, Chattogram, Bangladesh
  • Pijush Karmakar Assistant Professor, Dept. of Biochemistry, Eastern Medical College, Cumilla, Bangladesh
  • Hasan Murad Chowdhury Medical Officer, Chattogram City Corporation, Chattogram, Bangladesh
  • Prasun Barua Assistant Professor, Dept. of Biochemistry, Army Medical College, Chattogram, Bangladesh
  • Asma Hoque Assistant Professor, Dept. of Biochemistry, Institute of Applied Health Science, Chattogram, Bangladesh
  • Aklima Mazhar Assistant Professor, Dept. of Biochemistry, Bikrampur Bhuiyan Medical College, Munshiganj, Bangladesh

DOI:

https://doi.org/10.3329/emcj.v7i1.62721

Keywords:

Type-II DM, Serum hs-CRP, IR, HOMA-IR, BMI

Abstract

Background: Insulin resistance (IR) is the major event in type-ΙΙ diabetes mellitus followed by an increasing degree of β-cell dysfunction. Chronic inflammation is the driving force for IR and type-ΙΙ DM. The process of inflammation induces hepatic synthesis of high sensitivity C-reactive protein (an acute-phase protein) which plays a role in IR. The study was undertaken to find out the association of serum hs-CRP with insulin resistance in patients with type-ΙΙ diabetes mellitus.

Methodology: A hospital-based observational study was carried out in the Outpatient Department of Endocrinology, Chittagong Medical College Hospital and Department of Biochemistry, Chittagong Medical College. A total of 126 patients with type-II diabetes mellitus aged 40-64 years were included by non-probability consecutive sampling technique. Serum hs-CRP, fasting serum insulin was estimated. IR was calculated by using the Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR).

Results: The mean serum hs-CRP level was 9.1 ± 0.36 mg/L in patients with type-II DM. Serum hs-CRP was significantly associated with insulin resistance and positively correlated with HOMA-IR in type-II diabetics. Body mass index (BMI) as one of the key indicators of insulin resistance was also associated with serum hs-CRP in this study population. Additionally serum hs-CRP was correlated positively with BMI and fasting serum insulin in patients with type-II DM.

Conclusion: The results of this study concluded that increased serum hs-CRP was well associated and positively correlated with insulin resistance and its parameters signifying a possible role of subclinical inflammation in IR among patients with type-II diabetes mellitus.

EMCJ. January 2022; 7(1): 15-20

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Published

2022-11-07

How to Cite

Hossain, N. ., Haque, M., Karmakar, P. ., Chowdhury, H. M. ., Barua, P. ., Hoque, A., & Mazhar, A. (2022). Association of Serum High Sensitivity C-Reactive Protein with Insulin Resistance in Patients with Type-ΙΙ Diabetes Mellitus. Eastern Medical College Journal, 7(1), 15–20. https://doi.org/10.3329/emcj.v7i1.62721

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Original Article