TY - JOUR AU - Khanum, Hamida AU - Pervin, Shahanaj AU - Nessa, Zaibun AU - Rahman, ABM Mizanur PY - 2011/11/07 Y2 - 2024/03/29 TI - Comparative efficacy of albendazole, mebendazole and neem leaf extract in helminth infections in rat models JF - Dhaka University Journal of Biological Sciences JA - Dhaka Univ. J. Biol. Sci VL - 20 IS - 1 SE - Articles DO - 10.3329/dujbs.v20i1.8836 UR - https://www.banglajol.info/index.php/DUJBS/article/view/8836 SP - 41-48 AB - <p>Comparative efficacy of Albendazole, Mebendazole and neem leaf extract (<em>Azadirachta indica</em>) against <em>Vampirolepis nana, Hymenolepis diminuta </em>and <em>Syphacia muris </em>infections in laboratory rat strain Long-Evans (<em>Rattus norvegicus </em>Berkenhout, 1769) was evaluated. After treating with the drugs, egg reduction rate and cure rate from the worm infection were observed. Mebendazole had greater efficacy in terms of cure rate against <em>H. diminuta, </em>but in terms of egg reduction rate in <em>H. diminuta </em>infection<em>, </em>Albendazole had greater efficacy. The relative efficacy of Albendazole and Mebendazole were similar in terms of cure rate for <em>S. muris </em>infection (33.33%). In case of <em>H. diminuta, </em>both Albendazole and Mebendazole had nearly similar efficacy in terms of cure rate (20% vs. 25%). Albendazole had greater efficacy in terms of cure rate and egg reduction rate against <em>V. nana </em>than Mebendazole (25% vs. 16.67% and 28.57% vs. 10%). In case of <em>S. muris </em>infection<em>, </em>Mebendazole showed the higher egg reduction rate than Albendazole (20.09% vs 14.52%). Neem leaf extract had better efficacy on egg reduction rate in case of <em>S. muris </em>infection than Albendazole and Mebendazole. The relative efficacy of the neem extract was higher than that of the administred chemotherapy.</p><p><em>Key words: </em>Long-Evans; <em>Rattus norvegicus; </em>Comparative; Efficacy; Albendazole; Mebendazole; Neem leaf extract</p><p>DOI: <a href="http://dx.doi.org/10.3329/dujbs.v20i1.8836">http://dx.doi.org/10.3329/dujbs.v20i1.8836</a></p><p>Dhaka Univ. J. Biol. Sci. <strong>20</strong>(1): 41-48, 2011 (January)</p> ER -