TY - JOUR AU - Nahar, Shamsun AU - Parveen, Feroza AU - Ara, Ferdous AU - Faisal, Ferdous Mahmud PY - 2015/08/04 Y2 - 2024/03/19 TI - Effect of Pre-treatment with Moringa oleifera (Drumstick) Leaves on Diabetogenesis Produced by Alloxan in Rats JF - Delta Medical College Journal JA - Delta Med Col J VL - 3 IS - 2 SE - Original Articles DO - 10.3329/dmcj.v3i2.24424 UR - https://www.banglajol.info/index.php/DMCJ/article/view/24424 SP - 63-67 AB - <p><strong>Background: </strong>Medicinal plants constitute an important source of potential therapeutic agents for diabetes.</p><p><strong>Objective: </strong>In the study, we aimed to investigate the pre-treatment effect or preventive effects of Moringa oleifera (MO) leaves on blood sugar of rats.</p><p><strong>Materials and method: </strong>This experimental study was carried out in the department of Pharmacology and Therapeutics of Sir Salimullah Medical College in collaboration with Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka. A total 24 long Evans rats were included in this study and divided in to four groups. Hyperglycemia was induced on rats using alloxan (100 mg/kg body weight, intraperitioneally). Blood sample was collected from tail vein by tail tipping method. Pre-treatment effect or preventive role of Moringa oleifera (drumstick) leaf powder on diabetogenesis produced by Alloxan in rats was tested by giving 50 mg/rat/day Moringa oleifera leaf powder for 14 days orally as pre-treatment along with standard rat feed. Then alloxan was administered intraperitoneally on 15th day of the experiment and 50mg/rat/day Moringa oleifera leaf powder was given for 7 days as post-treatment.</p><p><strong>Results: </strong>No significant effect of MO on blood glucose level was observed on normal rats and non significant hypoglycaemic effect was found in rats that were pretreated with MO.</p><p><strong>Conclusion: </strong>The present study suggests that Moringa oleifera leaf powder did not produce any significant protective effect in diabetogenesis produced by alloxan though it has hypoglycaemic effect.<em></em></p><p><em>Delta Med Col J. </em>Jul 2015; 3(2): 63-67</p> ER -