Comparative Study of the Effect of Ethanol Extract of Psidium Guajava Linn Leaves with Glibenclamide on Experimentally Induced Diabetes Mellitus in Rats

  • Azmary Momtaz Assistant Professor, Dept. of Pharmacology and Therapeutics, Delta Medical College, Dhaka
  • Khaleda Sharmin Assistant Professor, Dept. of Pharmacology and Therapeutics, University Dental College, Dhaka
  • Sharmin Rahman Assistant Professor, Dept.of Pharmacology and Therapeutics, Ibrahim Medical College, Dhaka
  • Nashid Sultana Assistant Professor, Dept. of Pharmacology and Therapeutics, Delta Medical College, Dhaka
  • Rayhana Sharmin Lecturer, Dept. of Pharmacology and Therapeutics, Uttara Adhunic Medical College, Dhaka
Keywords: Diabetes mellitus, Psidium guajava, alloxan, blood glucose

Abstract

Background: Diabetes Mellitus is a major health problem not only in urban but also in the rural areas of Bangladesh. Regarding its treatment, a suitable drug is yet to be available which can permanently cure this disease. Over 400 traditional plants have been reported for the treatment of diabetes, but only a small number have received scientific and medical evaluation to assess their efficacy.

Objective: The study was performed to compare the anti diabetic effect of Psidium guajava Linn leaves with an oral anti diabetic drug (Glibenclamide), in experimentally induced diabetic rats.

Materials and method: The experiment was carried out in the department of Pharmacology & Therapeutics of Dhaka Medical College, Dhaka, Bangladesh from July 2012 to June 2013. Twenty four healthy rats of Long Evans Norwegian strain were divided into 4 groups (group A, B, C and D) comprising 6 rats in each. Group A (normal control) received standard rat food for 14 days. Diabetes was induced by administration of Alloxan 120 mg/kg/body weight in group B, C and D. Group B (diabetic control group) was given standard rat food. Group C and D was treated with ethanol extract of Psidium guajava leaves 100 mg/kg body weight and Glibenclamide 1.5 mg/kg/day orally respectively. Total duration of the experiment was 15 days.

Results: Administration of ethanol extract of Psidium guajava leaves in group C and Glibenclamide in group D produced a significant reduction (p<0.001) in blood glucose level as compared to group B (diabetic control group).

Conclusion: Ethanol extract of Psidium guajava leaves can be considered as a potential anti diabetic agent like Glibenclamide but it requires further investigations.

Delta Med Col J. Jan 2017 5(1): 9-14

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Author Biography

Azmary Momtaz, Assistant Professor, Dept. of Pharmacology and Therapeutics, Delta Medical College, Dhaka


Published
2017-02-04
How to Cite
Momtaz, A., Sharmin, K., Rahman, S., Sultana, N., & Sharmin, R. (2017). Comparative Study of the Effect of Ethanol Extract of Psidium Guajava Linn Leaves with Glibenclamide on Experimentally Induced Diabetes Mellitus in Rats. Delta Medical College Journal, 5(1), 9-14. https://doi.org/10.3329/dmcj.v5i1.31421
Section
Original Articles