Leucopenia as An Early Predictor of Thrombocytopenia and Hemorrhagic Manifestations in Dengue Fever: An Observational Study

Abstract

Background: Dengue fever is an endemic disease in Bangladesh that has shown in creasing incidence eachpassing year. Dengue has a wide range of clinical presenta tions and laboratory findings. Thrombocytopeniais a common finding in dengue-in fected patients along with other findings like leukopenia and hemorrhage in several forms. Thrombocytopenia is an indicator of disease severity andcan lead to severe bleeding manifestations. This study aims to find the association of leukopenia with thrombocytopenia and hemorrhagic manifestations. Materials and methods: This prospective observational study was conducted in a tertiary care hospital in Chattogram, Bangladesh for a period of six months. A total of 100 patients with confirmed dengue infection who fulfilled the inclusion criteria were followed from the day of admission to recovery. Clinical and laboratory findings, Total Leucocyte Count (TLC) and platelet counts were noted. Pearson’s Correlation Test was performed for correlation identification between leukopenia with thrombocytopenia and hemorrhagic manifestations in Dengue Fever. Results: Around 60.72% of the patients with bleeding manifestations had a low Platelet count (<150000/cmm) and among them 91.2% had leucopenia (><4000/cmm). A significant correlation was observed among low TLC, thrombocytopenia and hemorrhagic manifestation (p value ><0.001). Conclusion: Leucopenia has the potential to serve as an additional laboratory marker to predict thrombocytopenia and subsequent hemorrhagic manifestation in patients with dengue fever.><150000/cmm) and among them 91.2% had leucopenia (<4000/cmm). A significant correlation was observed among low TLC, thrombocytopenia and hemorrhagic manifestation (p value ><0.001). Conclusion: Leucopenia has the potential to serve as an additional laboratory marker to predict thrombocytopenia and subsequent hemorrhagic manifestation in patients with dengue fever><4000/cmm). A significant correlation was observed among low TLC, thrombocytopenia and hemorrhagic manifestation (p value <0.001).Conclusion: Leucopenia has the potential to serve as an additional laboratory marker to predict thrombocytopenia and subsequent hemorrhagic manifestation in patients with dengue fever.

Chatt Maa Shi Hosp Med Coll J; Vol.24 (2); July 2025; Page 58-61