The solubilization and extraction parameters of erythromycin from aqueous phase into mixed AOT/SB3-18 reverse micelle phase

Authors

  • SN Mohamad Aziz Faculty of Technology, Universiti Malaysia Pahang, 26300 Gambang, Pahang
  • AM Mimi Sakinah Faculty of Technology, Universiti Malaysia Pahang, 26300 Gambang, Pahang

DOI:

https://doi.org/10.3329/cerb.v19i0.33806

Keywords:

Solubilization, Erythromycin, Mixed micellar phase

Abstract

A liquid anionic-zwitterionic surfactant-based aqueous two-phase extraction was developed and applied for the extraction of erythromycin. Erythromycin solubilization from aqueous to reverse micelle phase was studied. Zwitterion SB3-18 surfactant was added to ionic solution of bis(2-ethylhexyl) sulfosuccinate sodium salt (AOT) to form an organic mixed micellar phase. Erythromycin was then added to the mixtures and two clear phases were formed. The parameters affecting erythromycin solubilization including AOT concentration (20.0 ? 120.0 g/L), zwitterion concentration (6.0 ? 16.0 g/L), NaCl concentration (0.0 ? 25.0 g/L) and aqueous pH (6.0 ? 9.0) were investigated via statistical software. Solubilization of erythromycin into mixed reverse micelle could be easily evaluated by the measurement of erythromycin concentration in the organic phase. The results showed that AOT and zwitterion concentration governed the erythromycin solubilization by a factor of 4.562 based on the Pareto chart.

Chemical Engineering Research Bulletin 19(2017) 123-128

Downloads

Download data is not yet available.
Abstract
745
PDF
1102

Author Biography

SN Mohamad Aziz, Faculty of Technology, Universiti Malaysia Pahang, 26300 Gambang, Pahang



Downloads

Published

2017-09-10

How to Cite

Aziz, S. M., & Sakinah, A. M. (2017). The solubilization and extraction parameters of erythromycin from aqueous phase into mixed AOT/SB3-18 reverse micelle phase. Chemical Engineering Research Bulletin, 19, 123–128. https://doi.org/10.3329/cerb.v19i0.33806

Issue

Section

Articles