@article{Hasnat_Dewan_Misbahuddin_Akhter_Shamsunnahar_Bhuiyan_2018, title={Folic acid, vitamin B12 and homocysteine levels following olanzapine administration in schizophrenia patients}, volume={11}, url={https://www.banglajol.info/index.php/BSMMUJ/article/view/34950}, DOI={10.3329/bsmmuj.v11i1.34950}, abstractNote={<p class="Abstract">The purpose of this study was to assess the levels of folic acid, vitamin B<sub>12</sub> and homocysteine in the serum of schizophrenia patients (n=20) and to evaluate the effect of olanzapine on these biomarkers. The blood was also collected from the 10 healthy volunteers as control. Compared to control, the serum folic acid (p=0.005) and vitamin B<sub>12</sub> levels (p=0.211) were higher in the schizophrenia patients, whereas no difference was evident in the serum homocysteine level. But significantly higher levels of serum folic acid (p=0.005), vitamin B<sub>12</sub> (p=0.047) and significantly lower level of serum homocysteine (p=0.000) were observed after 10 weeks of olanzapine administration. BPRS score was reduced significantly after intervention. The Pearson correlation coefficient test showed a statistically not significant negative relationship between the serum folate, vitamin B<sub>12</sub> and homocysteine levels. In conclusion, olanzapine can significantly elevate the  serum folic acid and vitamin B<sub>12</sub> levels whereas it can lower the serum homocysteine level which may contribute to the improvement of symptoms of schizophrenia.</p>}, number={1}, journal={Bangabandhu Sheikh Mujib Medical University Journal}, author={Hasnat, Fahmida and Dewan, Zesmin F. and Misbahuddin, Mir and Akhter, Nargis and Shamsunnahar, Jhunu and Bhuiyan, Habiba Akhter}, year={2018}, month={Mar.}, pages={11–16} }