Comparative Evaluation of Bromhexine HCl Mucoadhesive Microspheres Prepared by Anionic, Cationic and Nonionic Polymers

Authors

  • Sabirah Ishaque Limpa Department of Pharmacy, University of Asia Pacific, 74/A, Green Road, Dhaka-1205, Bangladesh
  • Zahirul Islam Department of Pharmacy, University of Asia Pacific, 74/A, Green Road, Dhaka-1205, Bangladesh
  • Md Selim Reza Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh

DOI:

https://doi.org/10.3329/bpj.v23i2.48331

Keywords:

Pharmaceutical Technology

Abstract

The purpose of this study was to formulate and assess the mucoadhesive microspheres of bromhexine hydrochloride, a mucolytic agent, using three different types of polymers to achieve gastric retention for improved solubility and bioavailability of the drug. The mucoadhesive formulation was prepared because it dissolved in the pH range of 1 to 4. The characteristics of the prepared microspheres were evaluated by determining the particle size, percent drug loading, surface morphology, swelling behavior, mucoadhesive bond strength and drug entrapment efficiency. The in vitro dissolution was studied using the USP dissolution apparatus I in 0.1N HCl (pH 1.2) media for 8 hours. The release kinetics were analyzed by using zero order, first order, Higuchi, Korsmeyer-Peppas and Hixon-crowell equations to explain the release mechanism from the microspheres. The microspheres exhibited good swelling index and the drug entrapment efficiency was above 79 % for all the formulations. All the formulations showed drug release above 25%, 35%, 50% and 75% after 2 hrs, 4 hrs, 6 hrs and 8 hrs of dissolution respectively. The mucoadhesive bond was observed up to 8 hrs in acidic media. The surface morphology of the prepared microspheres was studied by Scanning Electron Microscope (SEM) and no interaction was found between drug and polymer from the FTIR study.

Bangladesh Pharmaceutical Journal 23(2): 117-124, 2020

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Published

2020-07-23

How to Cite

Limpa, S. I., Islam, Z., & Reza, M. S. (2020). Comparative Evaluation of Bromhexine HCl Mucoadhesive Microspheres Prepared by Anionic, Cationic and Nonionic Polymers. Bangladesh Pharmaceutical Journal, 23(2), 117–124. https://doi.org/10.3329/bpj.v23i2.48331

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