Formulation and In-vitro Evaluation of Bilayer Tablets of Atenolol and Amlodipine

Authors

  • KM Yasif Kayes Sikdar Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh
  • Ahad Ahamed Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh
  • Md Mahbubul Alam Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh
  • Md Raihan Sarkar Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh
  • BK Sajeeb Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh

DOI:

https://doi.org/10.3329/bpj.v22i2.42299

Keywords:

Bilayer tablet, antihypertensive agents, atenolol, amlodipine.

Abstract

The present investigation was focused on formulation and in-vitro evaluation of a fixed dose bilayer tablet of two prominent antihypertensive agents, atenolol and amlodipine. The tablets were designed to immediately release atenolol (ATF1-ATF5) by using different percentage of sodium starch glycolate as super-disintegrant for prompt blood pressure lowering activity and sustain release amlodipine (AMF1- AMF5) by varying the percentage of hydroxy propyl methylcellulose (HPMC) for prolonged activity. After evaluation of the physical and chemical parameters of the formulations according to United States Pharmacopoeia (USP) guidelines, the best immediate release formulation was found in ATF1 in terms of dissolution (99.87% after 45 minutes) and other tablet properties like hardness, disintegration time, good flow properties etc. However, the best sustained release activity was found in AMF3 in terms of dissolution (99.98% after 24 hours with constant release) and other tablet properties. After optimization of the formulations, both atenolol and amlodipine parts were successfully compressed into bilayer tablets and post-compression parameters were evaluated. In 0.1 N HCl medium, the release of atenolol from bilayer tablet was found 98.97% after 45 minutes and in case of amlodipine it was found 98.12% in 0.1 N HCl medium followed by phosphate buffer medium after 24 hours. Drug release kinetics showed that the atenolol layer followed Case I, QasiFickian transport and amlodipine layer followed Anomalous (non-Fickian) transport. Compatibility study was conducted by using Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). Moreover, crystalline nature of substances and extent of its conversion to amorphous form was studied using X-ray Diffractometry (X-RD).

Bangladesh Pharmaceutical Journal 22(2): 153-169, 2019

Downloads

Download data is not yet available.
Abstract
1411
PDF
1477

Downloads

Published

2019-07-21

How to Cite

Sikdar, K. Y. K., Ahamed, A., Alam, M. M., Sarkar, M. R., & Sajeeb, B. (2019). Formulation and In-vitro Evaluation of Bilayer Tablets of Atenolol and Amlodipine. Bangladesh Pharmaceutical Journal, 22(2), 153–169. https://doi.org/10.3329/bpj.v22i2.42299

Issue

Section

Articles