Phytochemical and Toxicity Evaluation of Traditional Herb: Lagerstroemia speciosa L. (Banaba) by MCF-7 Cell Line and Brine Shrimp Lethality Bioassay

  • AK Azad Department of Pharmaceutical Technology, Department of Basic Medical Sciences, Faculty of Pharmacy International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
  • WS Azizi Department of Physical Rehabilitation Sciences, Faculty of Allied Health Sciences, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
  • AFH Ismail Department of Physical Rehabilitation Sciences, Faculty of Allied Health Sciences, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
  • Syed Atif Abbas Faculty of Pharmacy, Quest International University Perak, Malaysia
  • Jalal Uddin Department of Pharmacy, World University of Bangladesh, 151/8, Green Road, Dhaka-1205, Bangladesh
  • Zubair Khalid Labu Department of Pharmacy, World University of Bangladesh, 151/8, Green Road, Dhaka-1205, Bangladesh
Keywords: Cytotoxicity, Lagerstroemia speciosa, MCF-7, Brine Shrimp Lethality, MTT.

Abstract

The main objective of this study was to determine the cytotoxicity of crude extract of the leaves of Lagerstroemia speciosa (Banaba). In vitro MCF-7 cell line and in vivo brine shrimp lethality bioassay methods were followed to investigate the cytotoxicity of the selected sample. In this study, the qualitative phytochemical assessment demonstrated the presence of alkaloids, carbohydrate, glycosides, saponins, terpenes, steroids, phenols and flavonoids in Banaba extract. Moreover, the present findings revealed the non-cytotoxic nature of L. speciosa leaves extract on both MTT-assay and brine shrimp lethality bioassay.

Bangladesh Pharmaceutical Journal 22(1): 45-49, 2019

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Abstract
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Published
2019-01-31
How to Cite
Azad, A., Azizi, W., Ismail, A., Abbas, S., Uddin, J., & Labu, Z. (2019). Phytochemical and Toxicity Evaluation of Traditional Herb: Lagerstroemia speciosa L. (Banaba) by MCF-7 Cell Line and Brine Shrimp Lethality Bioassay. Bangladesh Pharmaceutical Journal, 22(1), 45-49. https://doi.org/10.3329/bpj.v22i1.40072
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Articles