Preparation and In vitro Evaluation of Mucoadhesive Tablets of Montelukast Sodium

Authors

  • Farzana Akter Bithi Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Tushar Saha Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Nusrat Ahmed Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Ikramul Hasan Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Selim Reza Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bpj.v20i2.37865

Keywords:

Direct compression, drug release, mucoadhesive polymers, mucoadhesive strength

Abstract

Mucoadhesive tablets of montelukast sodium were prepared in order to release the drug for a prolonged period of time so as to reduce the frequency of administration. Direct compression technique was applied using the mucoadhesive polymers which were Methocel K4M CR, Methocel K15M CR, Methocel K100M CR and Eudragit RLPO. Highest percent release of drug after 8 hours was 76% for Methocel K4M CR, 72.13% for Methocel K15M CR, 65.68% for Methocel K100M CR, 65.53% for the combination of Methocel K15M CR and Eudragit RLPO. Higuchi, Krosmeyer-Peppas was the best fitted model for drug release. The Methocel K15M CR containing drug showed good mucoadhesive strength. The highest ex-vivo mucoadhesive strength and ex-vivo residence time were observed with Methocel K15M CR and Eudragit RLPO combination. Fourier transform infrared (FT-IR) spectroscopy revealed the compatibility of drug with the polymers.

Bangladesh Pharmaceutical Journal 20(2): 123-131, 2017

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Published

2018-08-14

How to Cite

Bithi, F. A., Saha, T., Ahmed, N., Hasan, I., & Reza, M. S. (2018). Preparation and In vitro Evaluation of Mucoadhesive Tablets of Montelukast Sodium. Bangladesh Pharmaceutical Journal, 20(2), 123–131. https://doi.org/10.3329/bpj.v20i2.37865

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Articles