Development and Evaluation of Salbutamol Sulphate Loaded Ethyl Cellulose Microcapsules using Emulsion Solvent Evaporation Technique

Authors

  • Md Shamsul Alam Department of Pharmacy, The University of Asia Pacific, Dhanmondi, Dhaka-1209
  • Jakir Ahmed Chowdhury Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000
  • Sams Mohammad Anowar Sadat Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000
  • Md Selim Reza Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bpj.v18i2.24311

Keywords:

Ethyl Cellulose, Salbutamol Sulphate, Microcapsule, Emulsion-Solvent Evaporation Technique

Abstract

Ethyl cellulose (EC) microcapsules containing Salbutamol sulphate (SS) were prepared through emulsion-solvent evaporation technique. Microcapsules were compressed and in-vitro release profiles were studied from both microcapsules and their compressed matrix tablets. Different amounts of drug were added in order to obtain various drugs to polymer ratios and it was found that the size of microcapsules reduced with the increase in core loading. In the preparation of formulations, Tween 80 was used as an emulsifying or dispersing agent and light liquid paraffin (LLP) was used as oil phase. The in-vitro release of EC microcapsules was studied in distilled water at 37º ± 0.5°C. A biphasic release behavior of SS from microcapsules was observed. In case of microcapsules, an immediate release was observed but for their compressed tablet form, initially a burst effect and then slow release were observed which was extended for 8 hours. In order to further investigate the type of drug release mechanism, the dissolution data were plotted according to the different kinetic models. In-vitro dissolution studies showed that zero-order and square-root of time (Higuchi model) release characteristics were exhibited.

Bangladesh Pharmaceutical Journal 18(2): 132-136, 2015

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Author Biography

Md Shamsul Alam, Department of Pharmacy, The University of Asia Pacific, Dhanmondi, Dhaka-1209



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Published

2015-07-26

How to Cite

Alam, M. S., Chowdhury, J. A., Sadat, S. M. A., & Reza, M. S. (2015). Development and Evaluation of Salbutamol Sulphate Loaded Ethyl Cellulose Microcapsules using Emulsion Solvent Evaporation Technique. Bangladesh Pharmaceutical Journal, 18(2), 132–136. https://doi.org/10.3329/bpj.v18i2.24311

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