Analgesic and Neuropharmacological Activities of Methanol Extract from the Leaf of Nicotiana plumbaginifolia Viv.

Authors

  • Mehedi Shahriar Laborarory of Pharmacognosy and Phytochemistry, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217
  • Sadia Afreen Chowdhury Laborarory of Pharmacognosy and Phytochemistry, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217
  • Mohammad Zafar Imam Laborarory of Pharmacognosy and Phytochemistry, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217
  • Bidyut Kanti Datta Laborarory of Pharmacognosy and Phytochemistry, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217

DOI:

https://doi.org/10.3329/bpj.v18i2.24303

Keywords:

Nicotiana plumbaginifolia, Solanaceae, Analgesic, Neuropharmacology

Abstract

The aim of study was to evaluate the analgesic and neuropharmacological activities of the leaf of Nicotiana plumbaginifolia. The central analgesic activity of the methanolic extract was evaluated in Swiss Albino mice by using tail immersion, hot plate and acetic acid-induced writhing tests at 100, 200 and 400 mg/kg body weight. These tests showed significant analgesic activity of the extract compared to the standard drug, diclofenac-Na (1 mg/kg b.w.). The neuropharmacological activities were evaluated using hole cross, open field, light/dark box and elevated plus maze stage tests in mice model at 100, 200 and 400 mg/kg body weight. The results of neuropharmacological assays demonstrated potential CNS depressant activity of the extract when compared to the standard drug, diazepam (1 mg/kg b.w.)

Bangladesh Pharmaceutical Journal 18(2): 85-89, 2015

Downloads

Download data is not yet available.
Abstract
1085
PDF
1143

Author Biography

Mehedi Shahriar, Laborarory of Pharmacognosy and Phytochemistry, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217



Downloads

Published

2015-07-26

How to Cite

Shahriar, M., Chowdhury, S. A., Imam, M. Z., & Datta, B. K. (2015). Analgesic and Neuropharmacological Activities of Methanol Extract from the Leaf of Nicotiana plumbaginifolia Viv. Bangladesh Pharmaceutical Journal, 18(2), 85–89. https://doi.org/10.3329/bpj.v18i2.24303

Issue

Section

Articles