Design and Development of Sustained Release Microspheres of Ibuprofen by Emulsification Solvent Evaporation Method Using Polymeric Blend

Authors

  • Nandini Saha Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209
  • Ikramul Hasan Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209
  • Mehrina Nazmi Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209
  • Md Selim Reza Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bpj.v16i1.14489

Keywords:

Eudragit RSPO, Methocel K4M, Ibuprofen, Microsphere, Emulsification-Solvent Evaporation method

Abstract

Ibuprofen, a non-steroidal anti-inflammatory drug was formulated as microspheres by using Methocel K4M & Eudragit RSPO. These microspheres were prepared by emulsification solvent evaporation method to provide sustained action and to minimize local side effect of Ibuprofen by avoiding the drug release in the upper gastrointestinal tract. The prepared microspheres were subjected to various evaluation and in-vitro release studies. In-vitro drug release was studied in a paddle type dissolution apparatus (USP Type II Dissolution Apparatus) using Phosphate buffer (pH 7.4) as the dissolution medium at 37.5oC for 6 hours (paddle speed 50 RPM). The release mechanisms were explored and explained with Zero Order, First Order, Higuchi and Korsmeyer-Peppas equations. The correlation coefficients values of the trend lines of the graphs showed that the formulations best fit with Korsmeyer-Peppas release pattern. Microspheres morphology and chemical integrity were studied by a scanning electron microscope (SEM) and Fourier transforms infrared spectroscopy (FTIR) respectively.

DOI: http://dx.doi.org/10.3329/bpj.v16i1.14489

Bangladesh Pharmaceutical Journal 16(1): 39-44, 2013

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Published

2013-04-08

How to Cite

Saha, N., Hasan, I., Nazmi, M., & Reza, M. S. (2013). Design and Development of Sustained Release Microspheres of Ibuprofen by Emulsification Solvent Evaporation Method Using Polymeric Blend. Bangladesh Pharmaceutical Journal, 16(1), 39–44. https://doi.org/10.3329/bpj.v16i1.14489

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Articles