Distribution of High-risk Human papillomavirus genotypes among Woman with Cervical Precancerous Lesions Attending in Tertiary Care Hospital of Bangladesh
HPV Genotypes in Cervical Precancerous Lesions in Bangladesh
DOI:
https://doi.org/10.3329/bmrcb.v50i2.76638Keywords:
High risk Human papilloma virus genotype, precancerous lesion of cervix, high grade lesion, low grade lesionAbstract
Background: Human papillomavirus (HPV) is the most frequent cause of high-grade lesions and carcinogenesis, such as cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). However, the prevalence and genotype distribution of HPV infection varies greatly with respect to geographical regions. Determining the prevalence and distribution of HPV in a particular area is, therefore, of immense significance.
Objectives: This study was undertaken to evaluate the distribution of high-risk HPV genotypes in cervical precancerous lesions.
Methods: This descriptive cross-sectional study was conducted at the Colposcopy Clinic in the Department of Gynecologic Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka over a period of 6 months from November 2022 to April 2023. A total of 151 women aged between 30-70 years with Colposcopically abnormal and histopathologically proven precancerous lesions of the cervix were purposively included in the study. HPV-DNA test was done by US FDA-approved Digene's Hybrid Capture II (HCII) technology. However, the high-risk (HR) HPV DNA was assessed by PCR testing.
Result: In the present study majority (81.5%) of patients had low-grade CINs (CIN1), and the rest (18.5%) had high-grade lesions (CIN2 & CIN3). Over half of the patients tested positive for HPV DNA. The predominant genotype harbored by the patients was HPV16 (63.2%). The genotype HPV18 alone was negligible (3.3%6). The HPV16 and HPV18 together comprised 6.6%. While HPV 16 in association with other genotypes comprised 6%, HPV18 associated with other genotypes was the least (0.7%). About two-fifths (39%) of the low-grade CINs (CIN1) and all of the high-grade CINs (CIN2 & CIN3) were tested positive for HPV (p < 0.001). No significant association was found between HPV-DNA genotypes and CIN grade
Conclusion: The majority of women with CIN had low-grade lesions. Over half of the CIN patients have positive HPV-DNA test results. While HPV16 is the most prevalent genotype among the patients, the HPV18 genotype is uncommon. The prevalence of other genotypes are rare. All of the high-grade CINs and two-fifths of the low-grade CINs are found HPV-positive. Nevertheless, there is no significant association between CIN grade and HPV-DNA genotypes.
Bangladesh Med Res Counc Bull 2024; 50: 96-103
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Copyright (c) 2025 Shirin Akter Begum; Mehriban Amatullah, Tasfia Mahmud
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