Protective effects of the dietary supplementation of turmeric (<i>Curcuma longa</i> L.) on sodium arsenite-induced biochemical perturbation in mice

  • Md Rezaul Karim Department of Applied Nutrition and Food Technology, Islamic University, Kushtia and Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi
  • Abedul Haque Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi
  • Khairul Islam Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi
  • Narshad Ali Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi
  • Kazi Abdus Salam Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi
  • Zahangir Alim Saud Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi
  • Ekhtear Hossain Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi
  • Abul Fajol Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi
  • Anwarul Azim Akhand Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi
  • Seiichiro Himeno Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima
  • Khaled Hossain Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi
Keywords: turmeric

Abstract

The present study was undertaken to evaluate the protective effect of turmeric powder on arsenic toxicity through mice model. Swiss albino male mice were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were treated with turmeric powder (T, 50mg/kg body weight/day), sodium arsenite (Sa, 10mg/kg body weight/day) and turmeric plus Sa (T+Sa), respectively. Results showed that oral administration of Sa reduced the weight gain of the mice compared to the control group and food supplementation of turmeric prevented the reduction of weight gain. Turmeric abrogated the Sa-induced elevation of serum urea, glucose, triglyceride (TG) level and alanine aminotransferase (ALT) activity except the activity of alkaline phosphatase (ALP). Turmeric also prevented the Sa-induced perturbation of serum butyryl cholinesterase activity (BChE). Therefore, ameliorating effect of turmeric on Sa-treated mice suggested the future application of turmeric to reduce or to prevent arsenic toxicity in human.

DOI: 10.3329/bmrcb.v36i3.7287

Bangladesh Med Res Counc Bull 2010; 36: 82-88

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How to Cite
Karim, M., Haque, A., Islam, K., Ali, N., Salam, K., Saud, Z., Hossain, E., Fajol, A., Akhand, A., Himeno, S., & Hossain, K. (1). Protective effects of the dietary supplementation of turmeric (<i>Curcuma longa</i&gt; L.) on sodium arsenite-induced biochemical perturbation in mice. Bangladesh Medical Research Council Bulletin, 36(3), 82-88. https://doi.org/10.3329/bmrcb.v36i3.7287
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Research Papers