Comparative study of hydrochlorothiazide and indapamide on the anti-atherogenic potential of losartan in cholesterol fed rat

Authors

  • Md. Zakirul Islam
  • Md. Sayedur Rahman

DOI:

https://doi.org/10.3329/bmrcb.v36i1.5447

Keywords:

Anti-atherogenic, Cholesterol, Hydrochlorothiazide, Indapamide, Losartan, Rat

Abstract

The study was conducted to evaluate the anti-atherogenic potential of losartan and to assess the effects of hydrochlorothiazide and indapamide on losartan activity in rat. Cholesterol diet (0.5%) for 12 weeks led to significant hyperlipidemia, increased body weight and oxidative stress in erythrocyte. While, losartan, hydrochlorothiazide and indapamide treatment continued for next 12 weeks, losartan showed anti-atherogenic activity reflected by hypolipidemic effect and antioxidant effect in erythrocyte. This activity was abolished by addition of hydrochlorothiazide with losartan but remained unaltered by addition of indapamide with losartan. Atherosclerotic change and oxidative stress were not found in rat aorta, which may be due to short duration and low dose of cholesterol feeding. Hydrochlorothiazide treatment was associated with hypokalemia, which was not present in losartan or indapamide treatment. This study suggests that indapamide might be co-administered with losartan conserving the essential anti-atherogenic potential of losartan.

Online: 13 July 2010

DOI: http://dx.doi.org/10.3329/bmrcb.v36i1.5447

Bangladesh Med Res Counc Bull 2010; 36: 14-19


 

 

Downloads

Download data is not yet available.
Abstract
1945
PDF
689

Downloads

How to Cite

Islam, M. Z., & Rahman, M. S. (2010). Comparative study of hydrochlorothiazide and indapamide on the anti-atherogenic potential of losartan in cholesterol fed rat. Bangladesh Medical Research Council Bulletin, 36(1), 14–19. https://doi.org/10.3329/bmrcb.v36i1.5447

Issue

Section

Research Papers