Sympathetic cardiovascular function status of chronic obstructive pulmonary disease (COPD)
Background: Chronic obstructive pulmonary disease (COPD) is a chronic progressive obstructive airway disease which is often associated with cardiovascular diseases. Sympathetic dysfunction may complicate the cardiovascular diseases which may in turn increase the morbidity and mortality in COPD patients.
Objective: Aim of this study was to evaluate sympathetic cardiovascular function status of COPD patients to reduce the cardiovascular complication in those patients.
Methods: This comparative cross-sectional study was carried out at the department of Physiology and department of Medicine, Rajshahi Medical College, Rajshahi from July 2013 to June 2014.
Results: A total number of 80 subjects aged 40-55 years were selected, among which 40 were clinically diagnosed COPD patients (case) and 40 were age, sex and BMI matched apparently healthy persons for comparison (control group). To observe sympathetic cardiovascular function status resting pulse rate, resting systolic BP, resting diastolic BP, decline of systolic BP in response to standing from lying position (orthostatic test) and rise of diastolic BP in response to sustained hand grip for 5 minutes (isometric exercise test) were measured. For statistical analysis Independent sample t-test, and Pearson’s correlation coefficient test were performed. In this study resting pulse rate, systolic BP, diastolic BP and rise of diastolic blood pressure in isometric exercise test were significantly increased in COPD than in healthy control group. On the other hand, decline of systolic blood pressure in orthostatic test was significantly decreased in COPD than in control group.
Conclusion: This study concludes that sympathetic cardiovascular function is overactive in COPD and sympathetic over activity correlates with severity of the disease.
104 ONLINE VIEW
Copyright (c) 2019 BMRC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms.
Authors retain copyright and grant the journal right of first publication.
Articles in the Bangladesh Medical Research Council Bulletin are licensed under a Creative Commons Attribution 4.0 International License (CC-BY) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).