Tumor necrosis factor-α polymorphism in helicobacter pylori associated gastric carcinoma

  • Rita Rani Barua Department of Pathology, Dr. Sirajul Islam Medical College, Dhaka, Bangladesh
  • Sushanta Barua Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh.
  • Hena Rani Barua Department of Obstetric and Gynecology, Rangamati Medical College, Rangamati, Bangladesh.
  • Ajoy Kishore Barua Bandarban District Hospital, Bandarban, Bangladesh
  • M.A. Jalil Ansari Department of Endocrinology, Dhaka Medical College, Dhaka, Bangladesh
  • J-M Chong Department of Pathology, Tokyo Metropolitan Toshima Hospital, Tokyo, Japan
  • Hiroshi Uozaki Department of Pathology, The University of Tokyo, Tokyo, Japan.
  • Masashi Fukayama Department of Pathology, The University of Tokyo, Tokyo, Japan
Keywords: Tumor necrosis Factor-α, Helicobactor pylori, Gastric carcinomas, Polymorphism

Abstract

Background: Gastric cancer (GC) is the leading cause of cancer death in the world. Chronic inflammation is a predisposing factor of gastric carcinogenesis. TNF-α is a key pro-inflammatory cytokine secreted by macrophages and causes development of malignant diseases. It also plays an important role in chronic inflammation caused by Helicobacter Pylori. Therefore, TNF-α polymorphisms is studied in Helicobacter Pylori infected gastric cancer.

Objective: To find out the high risk group of Helicobacter Pylori infected gastric cancer cases in Asian and Caucasian people.

Methods: A total of 130 GC cases and 103 healthy controls from Jichi Medical School, Japan were studied. TNF-α genotype and allele frequency were studied by Restriction Fragment Length Polymorphism (RFLP).

Results: Among the study population TNFa-308A was less frequent in Asian people than those of Caucasian. TNFa-238G allele was more frequent in H. pylori positive GC (p<0.036) cases.

Conclusion: Findings of the study suggest that TNF-238G polymorphism of TNF-α gene may be closely associated with susceptibility to Helicobacter Pylori infected gastric cancer in Asian patients.  This might be due to high cytokine production by TNF-238G allele.

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Published
2019-12-30
How to Cite
Barua, R., Barua, S., Barua, H., Barua, A., Ansari, M., Chong, J.-M., Uozaki, H., & Fukayama, M. (2019). Tumor necrosis factor-α polymorphism in helicobacter pylori associated gastric carcinoma. Bangladesh Medical Research Council Bulletin, 45(3), 170-174. https://doi.org/10.3329/bmrcb.v45i3.44647
Section
Research Papers