Distribution of high risk Human Papilloma Virus genotypes among cervical cancer patients in a tertiary level hospital in Bangladesh

High risk Human Papilloma Virus genotypes

  • Munira Jahan Department of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh http://orcid.org/0000-0002-5976-0122
  • Tania Islam Department of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Sharmin Sultana Department of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Monira Pervin Department of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Prof. Ashrafunnessa Department of Gynae & Obstetrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Shahina Tabassum Department of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Keywords: Human papilloma virus, Genotype, INNO-LIPA, HPV 16 18

Abstract

Background: Cervical cancer is one of the most common types of cancer affecting women worldwide. Persistent HPV infection plays a major role in cervical cancer. The risk of cervical cancer has increased in parallel with the incidence of certain genotypes of human papilloma virus (HPV).

Methods: The study was aimed to detect the distribution of HPV genotypes among cervical cancer patients from a specialized hospital in Dhaka, Bangladesh. HPV DNA testing was done by polymerase chain reaction (PCR) using SPF-10 broad-spectrum primers followed by genotyping by reverse hybridization using the INNO-LIPA genotyping system at the Department of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka.

Results: HPV 16 was more prevalent (72.0%) in cervical cancer patients from Bangladesh followed by type 18 (6.0%) and 45 (2.0%). Genotype 16 and 18 alone and as co-infection were detected in 88.0% cases. Multiple HPV infection was found in 20% patients. Along with high risk (HR) HPV 16, 18 and 45 HR HPV 56, 39, 31 and 58 were also prevalent in multiple infections.

Conclusion: Thus the study concluded that HR HPV 16 and HPV 18 were more prevalent genotypes among cervical cancer patients in a specialised hospital in Bangladesh. Along with HR HPV 16 and HPV 18, HR HPV 45, 56, 39, 31 and 58 were also prevalent

Bangladesh Med Res Counc Bull 2019; 45: 86-92

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Published
2019-08-07
How to Cite
Jahan, M., Islam, T., Sultana, S., Pervin, M., Ashrafunnessa, P., & Tabassum, S. (2019). Distribution of high risk Human Papilloma Virus genotypes among cervical cancer patients in a tertiary level hospital in Bangladesh. Bangladesh Medical Research Council Bulletin, 45(2), 86-92. https://doi.org/10.3329/bmrcb.v45i2.42536
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Research Papers