Immune Response Among the Children to Hepatitis B Vaccination: A Community-based Study in Bangladesh

  • Mohammad Monir Hossain Bangabandhu Sheikh Mujib Medical University, Dhaka. http://orcid.org/0000-0001-6790-5048
  • Ahmed Nawsher Alam Disease Control and Research, Dhaka.
  • Mahmuda Siddiqua Ibn Sina Medical College, Dhaka.
  • Ayesha Siddika Mugda Medical College, Dhaka.
  • Afzalun Nessa Bangabandhu Sheikh Mujib Medical University, Dhaka.
Keywords: Hepatitis B Virus, Immune response, Antibody titre

Abstract

Hepatitis B virus infection is a vaccine preventable infection of liver which remains a key public health burden globally. The development of Anti-HBs titre greater than or equal to 10 IU/L is considered as protective immunity and any titre less than 10 IU/L as non-protective following HBV vaccination. There is no comprehensive and authentic data regarding the immune response even 10 years after the integration of the HBV vaccine in to the EPI programme in Bangladesh and specifically, in Brahmonbaria district. The study was also aimed to assess the long term immune response among HBV vaccinated children. Blood sample from 500 vaccinated children were tested for Anti-HBs, and anti-HBc. Sero negative children were given 1 dose of HBV vaccine as a booster. Samples from booster vaccine were taken one month later and tested for anti Hbs titre. Anti HBs titre was found below protective level in about 46.0% (230/500) participants. Sero-protection rate decreased to 72.2% in 5 to 6 years age group which further decreased to 58.3% in 7 to 9 years age group and increased again to 69.5% in 10 to 12 years age group children. On the other hand, the mean anti Hbs titre was 97.72 IU/L initially and then increased with the increasing of age from 165.40 IU/L to 196.67 IU/L. Breakthrough infection of HBV was seen in 1.2% (6/500) participants measuring by anti HBc which indicated protective efficacy of HBV vaccine was about 98.8% (494/500). Sero negative participants were given a booster dose; 93.6% (131/140) participants showed boosting of mean anti HBs titre upto 804.92 IU/L which was below protective level (<10 IU/L) before booster dose. Anti-HBs titre goes below with the increase of age after vaccination. Most of the participants had immunological memory which will boost antibody titre after any exposure, so routine booster dose is not needed. But non-responder to vaccination should screen after primary vaccination because of chance of breakthrough infection.

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Author Biographies

Mohammad Monir Hossain, Bangabandhu Sheikh Mujib Medical University, Dhaka.
Junior Consultant, Department of Paediatrics Neurology
Ahmed Nawsher Alam, Disease Control and Research, Dhaka.
Principal Scientific Officer, Department of Epidemiology
Mahmuda Siddiqua, Ibn Sina Medical College, Dhaka.
Associate Professor, Department of Microbiology
Ayesha Siddika, Mugda Medical College, Dhaka.
Lecturer, Department of Community Medicine
Afzalun Nessa, Bangabandhu Sheikh Mujib Medical University, Dhaka.
Associate Professor, Department of Virology
Published
2018-11-22
How to Cite
Hossain, M., Alam, A., Siddiqua, M., Siddika, A., & Nessa, A. (2018). Immune Response Among the Children to Hepatitis B Vaccination: A Community-based Study in Bangladesh. Bangladesh Medical Research Council Bulletin, 44(2), 103-108. https://doi.org/10.3329/bmrcb.v44i2.38705
Section
Research Papers