Association of High Sensitive C - Reactive Protein with Severity of the Left Ventricular Systolic Dysfunction in Acute Anterior ST Elevation Myocardial Infarction

  • Aparna Rahman BIRDEM General Hospital, Dhaka. http://orcid.org/0000-0002-3271-7239
  • Abdul Wadud Chowdhury Dhaka Medical College Hospital, Dhaka.
  • Lutfur Rahman Khan Dhaka Medical College Hospital, Dhaka.
  • Khandkar Md. Nurus Sabah Dhaka Medical College Hospital, Dhaka.
  • Mohammad Gaffar Amin Dhaka Medical College Hospital, Dhaka.
  • S.M. Alauddin Al Azad Popular Hospital, Narayanganj.
Keywords: High Sensitive C-reactive protein (hs- CRP), Left Ventricular Systolic Dysfunction (LVSD)

Abstract

High Sensitive C-reactive protein (hs- CRP) is an established risk marker in coronary artery disease. It is a marker of inflammation activated early after Acute Myocardial Infarction (AMI) and its quantity depends upon extent of myocardial damage. Release of inflammatory marker occur after acute myocardial infarction leading to cardiac remodeling which clinically manifests as Heart failure (HF). Heart failure is a common complication after acute anterior myocardial infarction (AMI). The prevalence of post-infarct Left Ventricular Systolic Dysfunction (LVSD) ranges from 27 to 60 % and half of patients having early post-infarct LVSD subsequently develop chronic heart failure. The purpose of this study is to show association between hs-CRP with LVSD in AMI and early detection of HF. This was a cross-sectional analytical study in which hs-CRP was done among all the study subjects between 24-48 hours after onset of AMI. The study population was categorized into groups I, II, II according to the lowest to highest hs-CRP level. Transthoracic echocardiography was done between 24-48 hours of anterior ST Elevation Myocardial Infarction (STEMI). Then LVSD was assessed between those three groups and searched for association. Severely reduced ejection fraction (EF) was found in patients of group III (highest hs-CRP tertile) only. Severe and moderately reduced EF and FS was found significantly more in group III and II than group I (mid and lowest hs-CRP tertile) (p<0.001). High level of hs-CRP in patient of acute anterior STEMI patients was associated with moderate to severe reduction in EF and Fractional Shortening (FS).  So hs- CRP may be a prognostic marker in acute anterior STEMI complicating LVSD and early management would improved the short and long term prognosis.

Downloads

Download data is not yet available.
Abstract
101
PDF
47 ONLINE VIEW
12

Author Biographies

Aparna Rahman, BIRDEM General Hospital, Dhaka.
Senior Medical Officer, Department of Cardiology
Abdul Wadud Chowdhury, Dhaka Medical College Hospital, Dhaka.
Professor & Head, Department of Cardiology
Lutfur Rahman Khan, Dhaka Medical College Hospital, Dhaka.
Former Professor & Head, Department of Cardiology
Khandkar Md. Nurus Sabah, Dhaka Medical College Hospital, Dhaka.
Assistant Professor, Department of Cardiology
Mohammad Gaffar Amin, Dhaka Medical College Hospital, Dhaka.
Assistant Professor, Department of Cardiology
Published
2018-11-22
How to Cite
Rahman, A., Chowdhury, A., Khan, L., Sabah, K., Amin, M., & Al Azad, S. (2018). Association of High Sensitive C - Reactive Protein with Severity of the Left Ventricular Systolic Dysfunction in Acute Anterior ST Elevation Myocardial Infarction. Bangladesh Medical Research Council Bulletin, 44(2), 71-76. https://doi.org/10.3329/bmrcb.v44i2.38689
Section
Research Papers