Acute and long-term neurological complications in children with acute lymphoblastic leukemia

Authors

  • A.T.M. Atikur Rahman Department of Pediatric Hemato-Oncology, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh.
  • M.A. Mannan Department of Pediatric Hemato-Oncology, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh.
  • Samia Sadeque Department of Pediatric Hemato-Oncology, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh.

DOI:

https://doi.org/10.3329/bmrcb.v34i3.1858

Keywords:

Acute lymphoblastic leukemia, children, neurological complication

Abstract

The pattern of acute and long-term neurological complications in 133 children with acute lymphoblastic leukemia (ALL) treated with two treatment protocol was reviewed. Twenty patients developed neurological complications. Nine out of 20 patients received MRC UK ALL X and the remaining 11 received MRC UK ALL XI protocol. There was no difference of neurological complications between MRC UKALL X and UK ALL XI protocol groups. The numbers of patients who developed neurological complications during induction of remission period were 11 of 133 patients (8.2%). 122 patients were observed during the maintenance period of treatment (from 6 months to 36 months). Six out of 122 patients developed neurological complications during this period. 88 patients were followed for a period of up to 6 months after the cessation of chemotherapy, i.e., in the late period. Neurological complications were found in 3 during this period. Neurological complications rate was 4 times higher in the relapsed group than in the no relapsed group (p < 0.05). Systemic chemotherapy (including vincristine, high-dose methotrexate) and intrathecal chemotherapy seem to be the most common predisposing factors.

Keywords: Acute lymphoblastic leukemia; children; neurological complication

Online: 29-1-2009

DOI: 10.3329/bmrcb.v34i3.1858

Bangladesh Med Res Counc Bull 2008; 34: 90-93

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How to Cite

Rahman, A. A., Mannan, M., & Sadeque, S. (2009). Acute and long-term neurological complications in children with acute lymphoblastic leukemia. Bangladesh Medical Research Council Bulletin, 34(3), 90–93. https://doi.org/10.3329/bmrcb.v34i3.1858

Issue

Vol. 34 No. 3 (2008)

Section

Research Papers

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