Sustained virological response after treatment in patients with chronic hepatitis C infection - a five year follow up

  • MZ Rahman Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • DS Ahmed Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • H Masud Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • S Parveen Department of Paediatrics, BSMMU, Dhaka
  • MA Rahman Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • MS Chowdhury Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • R Barua Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka,
  • SM Ishaque Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
Keywords: hepatitis C infection

Abstract

Peginterferon ?-2a and ribavirin combination therapy achieves a sustained virological response (SVR) in patients with chronic hepatitis C. Little is know about long-term durability of hepatitis C virus Ribonucleic acid (HCV-RNA) negativity in patient treated with pegylated interferon and ribavirin therapy. Aim of this study was to evaluate the durability of virologic response in patients with SVR to anti-viral therapy treated at our centre. A total of 52 patients with chronic hepatitis C virus infection who had obtained SVR after Peginterferon ?-2a and ribavirin combination therapy were followed up to 5 years with annual HCV-RNA testing. During this follow up period, 4 of 52 patients with initial SVR developed late relapse of hepatitis C virus infection. Relapse was more common in patients who has cirrhosis (3/6 [50%]) vs (1/46 [2.17%]) without cirrhosis. In conclusion, SVR is durable in most patients, but some patients do have late relapse; long term follow up may be particularly important in a subset of patients with hepatitis C virus infection who have liver cirrhosis.

DOI: http://dx.doi.org/10.3329/bmrcb.v39i1.15791

Bangladesh Med Res Counc Bull 2013; 39: 11-13

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Abstract
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PDF
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Published
2013-07-23
How to Cite
Rahman, M., Ahmed, D., Masud, H., Parveen, S., Rahman, M., Chowdhury, M., Barua, R., & Ishaque, S. (2013). Sustained virological response after treatment in patients with chronic hepatitis C infection - a five year follow up. Bangladesh Medical Research Council Bulletin, 39(1), 11-13. https://doi.org/10.3329/bmrcb.v39i1.15791
Section
Research Papers